Endocrine Abstracts

Introduction: Obesity is a multifactorial disease in whose genetic factors are involved. The integration of this factors will allow to state personalized prevention strategies, where the constant contact with the patient will have a greater success for them to follow up recommendations. Continuous technological changes allow bigger accessibility to communication, having platforms with remote control.

Objective: Assessing the effectiveness of an Intelligent Platform of Biomedical to Monitor, Treat and Personalized Prevention in obesity and cardiometabolic risk versus a non technological intervention for the obesity treatment, considering the participants’ genetic characteristics.

Materials and methods: 71 obese subjects, between 18 and 65 years, of the PREDIRCAM study (prospective cohortes intervention study) were included. Recruitment, the participants were randomized in intensified intervention group (control group) or technological intensified intervention group (intervention group). The follow up was made for 6 months. Anthropometric data, biochemical data and environmental data with questionnaires were obtained. The rs12324955 of the FTO gene was determined through TaqMan probes.

Results: 88.7% were women. After 6 months, data of 46.5% to the sample were obtained, because the rest had not completed the full term yet. After 6 months of intervention the subjects showed less weight, hip and BMI (weight: −4.39±5.61 kg; hip: −3.93±5.11 cm; BMI: −1.63±1.96 kg/m², P<0,001 in all cases). When dividing according to the intervention group, technological group subjects showed also a significant reduction in the total and c-LDL according to the baseline (total cholesterol: −15.47±21.01 mg/dl, P=0.008; c-LDL: −10.19±14.77 mg/dl P=0.015). According to the genotype rs12324955 no differences were found in at baseline, but after intervention the carriers of the A allele showed a light greater decrease in weight that GG homozygotes (A carriers: −5.88±5.00 kg, P<0.001; GG homozygotes: −3.96±2.95 kg, P=0.002). After segmenting by the intervention group, everybody lost weight significantly after intervention, these differences were more significant in carriers of the A allele of the technological group (non technological: carriers A: −6.07±6.41 kg P=0.022, GG homozygotes: −4.50±4.78 kg P=0.047; technological: carriers A: −5.66±3.16 kg P=0.001, GG homozygotes:- 3.49±3.33 kg P=0.021).

Conclusion: The intensive intervention to modify the obese people’s lifestyle shows a decrease in weight loss, being this intervention more effective in rs12324955 carriers A subjects and with intervention done using technological applications.