Are there differences in cardiovascular risk between metabolically healthy and sick obese?

Alhambra Exposito Maria Rosa; Jimenez Concepcion Munoz; Continente Alfonso Calanas; Molina Puerta Maria Jose

doi:10.1530/endoabs.56.P555

Introduction: Obesity is a major health problem and a risk factor for the development of other diseases. However, there are morbid obese subjects of long evolution that can be considered metabolically healthy obese, whose existence is in doubt for many clinicians.

Objetive: To analyze if there are differences in cardiovascular risk between metabolically healthy (MHO) and sick obese (MSO), matched by age, sex and body mass index (BMI).

Material and methods: We include patients who underwent bariatric surgery in our hospital. We divided them into two groups (MHO and MSO), matched by age (+/- 3 years), BMI (according to the obesity degrees) and by sex. The MHO were defined because they did not meet any criteria of the ATP III and because they did not have previous cardiovascular disease.

Results: 164 patients were included. Basal characteristics were show in table 1. MHO had higher HDL level, lower triglycerides, glucose, HbA1c and lower values of systolic and diastolic blood pressure than MSO. The cardiovascular risk measured by Score was significantly lower in the MHO (0.04±0.19), than MSO (0.26±0.81), P 0.019). The same happened with the Framingham scale (MHO 0.04±0.190 vs MSO 4.04±3.66, P 0.001)


	MHO	MSO	P-value
Age (years)	38.46±10.40	38.57±10.21	0.946
Sex (♀ - ♂ %)	80.5 – 19.5	80.5 – 19.5	1
BMI (Kg/m²)	50.51±8.45	50.38±7.64	0.916
Maximum weight (Kg)	136.89±22.35	140.22±28.85	0.348
Lost exccess wetht. (%)	59.81±22.59	56.47±23.12	0.378
Dyslipidemia (%)	0	19.6	0.001
Total colesterol (mg/dl)	175.42±34.61	176.49±39.43	0.855
HDL –c (mg/dl)	57.71±9.33	43.59±10.59	0.000
LDL –c (mg/dl)	109.26±28.08	118.46±35.06	0.066
Triglycerides (mg/dl)	90.07±30.70	115.44±6.76	0.002
DM (%)	0	34,3	0.001
Glucose (mg/dl)	89.62±7.70	105.35±38.74	0.000
HbA1c (%)	5.70±0.58	6.29±1.64	0.020
HTA (%)	0	36,6	0.001
TA S (mmHg)	119.19±8.14	128.79±19.06	0.000
TA D (mmHg)	71.68±6.62	78.33±13.57	0.000
Smoke (%)	22	23.2	0.454

Conclusions: In our series, MHO have a lower cardiovascular risk both for the scale and for Framinghan, adjusting for age, sex and degree of obesity.

Endocrine Abstracts

P555