ECE2018 Poster Presentations: Diabetes, Obesity and Metabolism Obesity (78 abstracts)
The relationship between obesity, insulin resistance and conjunctival impression cytology
Murat Dağdeviren 1 , Mustafa Altay 1 , Zennure Yıldız 2 , Gülçin Şimşek 3 , Mehmet Çıtırık 4 , İhsan Ateş 5 , Tanyel S Dağdeviren 6 , Canan Yıldız 7 & Tuğba Şahin 2
1Department of Endocrinology and Metabolism, Sağlık Bilimleri University, Keçiören Health Administration and Research Center, Ankara, Turkey; 2Department of Ophthalmology, Sağlık Bilimleri University, Keçiören Health Administration and Research Center, Ankara, Turkey; 3Department of Pathology, Sağlık Bilimleri University, Keçiören Health Administration and Research Center, Ankara, Turkey; 4Department of Ophthalmology, Sağlık Bilimleri University, Ulucanlar Health Administration and Research Center, Ankara, Turkey; 5Department of Internal Medicine, Sağlık Bilimleri University, Ankara Numune Health Administration and Research Center, Ankara, Turkey; 6Department of Family Practice, Sağlık Bilimleri University, Keçiören Health Administration and Research Center, Ankara, Turkey; 7Department of Internal Medicine, Sağlık Bilimleri University, Keçiören Health Administration and Research Center, Ankara, Turkey.
Introduction: This study was designed to determine whether obesity causes inflammation on both conjunctival epithelium cells as well as on squamous metaplasia.
Materials and methods: Around 61 volunteer participants who had no previous history of illness or drug use were involved in this study. Of them, nearly 20 were obese, and 41 were of normal weight. We measured the glucose and insulin values for all volunteers. We also measured the Body Mass Index (BMI) and Homeostasis Model Assessment for Insulin Resistance (HOMA IR). The impression cytology method was used to analyze the conjunctival epithelium cells and classify them between Grades 0 to 3 according to the Nelson criteria.
Results: While there was a certain level of inflammation on the 90% of, as well as squamous metaplasia (Grade 2-3 inflammation) on the 80% of obese participants, the impression cytology was found to be normal only in two patients. The expected results were observed on the 56.1% of the control group, and the squamous metaplasia rate was nearly 17% (P<0.001). 90.9% of the patients with grade 3 inflammation were obese. The variables as independent predictors were found to indicate the existence of inflammation in conjunctivae at various levels; BMI (OR:1,24; P=0.002) and HOMA IR (OR=28.6; P=0.001) in a Model I multivariable regression model, and the existence of obesity (OR:11.91; P=0.002) and HOMA IR (OR=15.08; P<0.001) in a Model II multivariable regression model.
Conclusion: Obesity was found to be a disorder that causes inflammation on the conjunctival epithelium cells for the first time.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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