ECE2018 Poster Presentations: Diabetes, Obesity and Metabolism Female Reproduction (1 abstracts)
Non-alcoholic fatty liver disease and polycystic ovarian syndrome in lean and obese women of reproductive age
Athina Markou 1 , Krystallenia Alexandraki 2 , Evita Kafritsa 1 , Ioannis Androulakis 1 , Vasiliki Syriou 3 , Labrini Papanastasiou 1 , Eleni Antipa 4 , Ageliki Tsikini 4 , Christianna Samara 4 , George Piaditis 2 & Gregory Kaltsas 2
1Department of Endocrinology and Diabetes Center, General Hospital of Athens ‘G.Gennimatas’, Athens, Greece; 2Endocrine Unit, 1st Department of Propaedeutic Medicine, Laiko University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece; 3Pathophysiology Department and First Department of Internal Medicine, Laikon General Hospital and Medical School, National and Kapodistrian University of Athens, Athens, Greece; 4Department of Radiology, General Hospital of Athens ‘G.Gennimatas’, Athens, Greece.
Introduction: Non-alcoholic fatty liver disease (NAFLD) is the commonest cause of chronic liver disease in the western world affecting 5-33% of the general population. Polycystic ovarian syndrome (PCOS) is a common endocrinopathy affecting 6-10% of women of reproductive age. In both conditions, insulin resistance (IR) seems to be a common pathogenetic mechanism.
Objective: To investigate the presence of NAFLD in lean and obese women with and without PCOS using biochemistry and imaging modalities such as liver ultrasound (U/S) and computed tomography (CT).
Patients and methods: Eighteen lean and 17 obese control women and 21 lean and 21 obese women with PCOS were studied prospectively. Baseline biochemical profile was followed by a glucose tolerance test and indices of IR were calculated. Ovarian morphology was assessed using transvaginal ultrasonography. Hepatic lipid content was assessed with U/S and CT of the liver.
Results: Mean age was 26 years for all four groups. Mean BMI(±SD) was 21.0±1.8 kg/m2 for lean controls and 21.4±1.9 for lean PCOS and 33.0±7.4 kg/m2 for obese controls and 34.6±6.4 for obese PCOS. Fasting insulin levels and indices of IR showed an incremental continuum trend from the lean controls to lean PCOS to obese controls to obese PCOS. Hepatosteatosis assessed by liver U/S was seen in 15% of lean PCOS, in 37% of obese controls and in 50% of obese PCOS women. Evidence of hepatosteatosis was only found in 1 obese patient with PCOS on liver CT. In the whole population studied there was a negative correlation between waist circumference and mean liver-mean spleen attenuation on liver CT. Age, BMI, waist circumference, ALT levels and insulin resistance were independent risk factors associated with NAFLD as assessed on U/S, in lean and obese women of reproductive age with and without PCOS.
Conclusions: NAFLD in more common in obese than lean women with or without PCOS as evaluated by radiologic modalities. Obesity and IR play a determinant role in the development of the disease. Ultrasound is 100% whereas CT is 93% sensitive in detecting NAFLD only when fatty infiltration is at least 33%. Newer methods such as magnetic resonance spectroscopy (MRS) would help to diagnose the disease at earlier stages.
Volume 56
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more