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Endocrine Abstracts (2018) 56 P485 | DOI: 10.1530/endoabs.56.P485

Hospital Universitario Reina Sofía, Córdoba, Spain.


Objective: To evaluate the efficacy of canagliflozin 100 mg for glycemic control and progression of weight loss after stabilization with liraglutide 1.8 mg.

Patients and methods: Descriptive study: patients with type 2 diabetes (DM-2) in treatment with metformin and liraglutide 1.8 mg, optimal metabolic control, which after stabilization in weight loss, liraglutide is suspended and canagliflozin 100 mg is added. Variables analyzed baseline and at 6 months after treatment change: age, sex, time of diabetes evolution, Body mass index (BMI), abdominal perimeter (BP), systolic blood pressure (SBP), diastolic blood pressure (DBP), LDL, HDL, triglycerides (TG), uric acid (UA). Statistical analysis: comparing means with Student’s test.

Results: Eighteen patients. 50% women Age: 55.61±7.1 years. Time of diabetes evolution: 7.7±5 years. Weight loss achieved 6 months after the change of treatment was 6±2.5 Kg. No side effects were recorded. The treatment change was satisfactory for all patients.

Basal (mean ± SD)6 months (mean ± SD)P
Weight (Kg) 97.5±10.891±10.90.1
BMI (kg/m2) 35.2±2.333.1±2.20.01
BP (cm) 110.3±9.4105.7±8.60.1
SBP (mmHg)137.5±8.5128.9±7.10.002
DBP (mmHg)84.6±14.475.5±7.10.02
HbA1c (%)7±0.26.5±0.30.000
LDL (mg/dl) 104.5±32.189.3±220.11
HDL (mg/dl) 46.8±849.5±6.70.3
TG (mg/dl) 164.5±74.2125.8±44.40.06
UA (mg/dl) 7.2±0.96.5±1.20.05

Conclusions: The change of treatment of liraglutide 1.8 mg to canagliflozin 100 mg in patients with optimal glycemic control and stabilization weight loss, achieves a progression in weight loss and improves the metabolic control of the patient with DM-2. The change of treatment was satisfactory for all patients. No side effects were recorded.

Volume 56

20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

European Society of Endocrinology 

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