Endocrine Abstracts

Objective: To evaluate the efficacy and safety of Traditional Chinese medicine formula (Simiao Yong’an Decoction) in the treatment of Diabetic foot (DF).

Methods: A comprehensive retrieval was made in PubMed, EMRS, EMbase, The Cochrane Library, CNKI, WanFang and other databases to collect randomized controlled trials (RCTs) on the treatment of DF with Simiao Yong’an Decoction (from the establishment of databases to Dec 2017). Two reviewers independently screened literature, extracted data and assessed the risk of bias. RevMan 5.3 software was used to perform Meta-analysis. The control groups was treated by conventional Western therapy (anti-infectives, anticoagulant, promote the blood circulation), while the intervention groups was treated by Simiao Yong’an Decoction. There was no statistically significant on the levels of blood glucose between these two groups. The curative effect was measured by clinical curative effect, the blood flow in the dorsalis pedis, ankle brachial index, side effects. The therapy was sustained at 8 weeks.

Results: Seven RCTs were enrolled in the study, with a total of 485 patients. The Meta-analysis results showed that compared with the conventional therapy, Simiao Yong’an Decoction had advantages in improving clinical curative effect (OR=1.15, 95% CI=[1.07, 1.24], P=0.000 2), and enhance the blood flow in the dorsalis pedis (WMD =1.40, 95% CI=[0.94, 1.86], P<0.000 01) and increase the ankle brachial index (WMD=0.07, 95% CI=[0.02, 0.12], P=0.005). While there was no statistically significant on adverse events.

Conclusion: Simiao Yong’an Decoction may have advantages over Western medicine in the treatment of DF, and it is a form of recommendable adjuvant therapy for DF. In view of the limited quantity and quality of the included studies, it is needed to verify with more high quality randomized controlled trials.