Endocrine Abstracts

Background: Insulin pumps, devices for continuous subcutaneous insulin infusion have become fundamentally new and progressive step in the treatment of diabetes. To date, there has been no experience with the use of insulin pumps in Uzbekistan

Aims and objectives: To evaluate the effectiveness of insulin pump therapy in comparison with the regime of multiple daily injections (MDI) of insulin.

Materials and methods: Forty children and adolescents with type 1 diabetes from 5 to 17 years (28 girls and 12 boys) were examined. All patients were divided into 2 groups. Group 1 consisted of patients who were transferred from the baseline bolus scheme of insulin therapy with human insulin to MDI with combination of a human insulin analog and a short-acting insulin. Group 2 includes patients who were transferred to pump insulin therapy and received ultrashort acting insulins. Glycemia and glycated hemoglobin were monitored Within 12 months,

Results: The comparative analysis showed a significant decrease in glycated hemoglobin (7.9+0.3) by 2.3% in group 2, compared with children and adolescents on the MDI regime (HbA1c 7.8+0.3%, decrease by 1.5%). The proportion of patients with a HbA1c level of less than 7.5% on MDI increased from 20% to 50%, and in the group receiving insulin pump therapy increased from 15% to 50%. Target values of HbA1c <7.5% reached 50% of patients in groups 1 and 2.

Conclusion: On insulin pump therapy HbA1c decreased by 2.3%. The target values of HbA1c reached 50% of the patients in both groups.