ECE2018 Poster Presentations: Diabetes, Obesity and Metabolism Diabetes complications (72 abstracts)
Serum lipid changes during pregnancy and after delivery in women with previous gestational diabetes
Montserrat Prados 1, , Juana A Flores-Le Roux 2, , David Benaiges 2, , Gemma Llauradó 2, , Juan José Chillarón 2, , Verónica Amador 3 , Cristina Bosch 3 , Antoni Paya 4 & Juan Pedro-Botet 3,
1Hospital Sant Joan de Deu de Martorell, Martorell, Spain; 2Departament of Medicine, Universitat Autonoma de Barcelona, Barcelona, Spain; 3Endocrinology and Nutrition Department, Hospital del Mar, Barcelona, Spain; 4Obstetrics and Gynecology Department, Hospital del Mar, Barcelona, Spain.
Background: Women with a history of gestational diabetes mellitus (GDM) are at increased risk for diabetes and lipid alterations.
Objective: In a cohort of women with previous GDM, we aimed to ascertain whether women with abnormal glucose tolerance one year post-delivery had a more atherogenic lipid profile after pregnancy than those with normal glucose tolerance.
Design and patients: A descriptive study of GDM women who underwent pre and postnatal follow-up at the Hospital del Mar, Barcelona between January 2004 and March 2016 was conducted.
Results: Three hundred and six (56.8%) of 537 women diagnosed of GDM during the studied period, attended a control visit during the first year after delivery. The incidence of type 2 diabetes mellitus (T2DM) and prediabetes in these patients was 5.2% and 36.6%, respectively. High-density lipoprotein (HDL) cholesterol remained significantly lower in women with T2DM (48±11 mg/dl vs 59±12 mg/dl; P=0.009) and the prediabetes group (54±13 mg/dl vs 59±12 mg/dl; P=0.029) at the first year postpartum than in those with normal glucose tolerance. Additionally, triglycerides were higher in the T2DM group compared with the normal glucose tolerance group (128±60 mg/dl vs 89±41 mg/dl; P=0.009). There were no differences in LDL cholesterol levels within the three groups.
Conclusions: Women with previous GDM who develop T2DM or prediabetes one year post-delivery have lower HDL cholesterol concentrations than those with normal glucose tolerance. Moreover, those who develop T2DM have higher triglyceride concentrations than those with normal glucose tolerance.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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