ECE2018 Poster Presentations: Diabetes, Obesity and Metabolism Diabetes complications (72 abstracts)
Endothelial dysfunction in the diabetic foot
Edward Jude 1, , Janice Mascarenhas 1, , Deepak Bhatnagar 2 , R Weston 1 , Fiona Wilkinson 1 & Yvonne Alexander 1
1Manchester Metropolitan University, Manchester, UK; 2University of Manchester, Manchester, UK; 3Tameside Hospital NSH Foundation Trust, Ashton under Lyne, UK.
Endothelial dysfunction (ED) is common in type 2 diabetes mellitus (T2DM) and can lead to microvascular and macrovascular complications. The aim of our study was to assess ED in patients with T2DM (n=21; 13 with diabetic neuropathy (DN), 8 without DN) and compare them with non-diabetic controls (n=10).
Methods: ED was assessed by skin microcirculation (SM) and biochemical markers (BM) of endothelial function. SM was measured on the dorsum of the foot by laser Doppler (LD) iontophoresis using the Perimed Laser Doppler Imager. Endothelial-mediated vasodilation (EMV) was measured by the iontophoresis of acetylcholine (Ach), while sodium nitroprusside (SNP) was used to study endothelium-independent vasodilation (EIV). Fasting blood samples were collected at baseline for markers of endothelial activation (ICAM, VCAM and inflammatory molecules like IL-6).
Results: Patients in the control group were younger and had lower BMI and HbA1c. There was no difference in skin microcirculation between groups, for both EMV and EIV. There was also no difference in biochemical markers of ED including ICAM, VCAM, however, there was a significant up-regulation of IL-6 in T2DM (P=0.006)
Conclusions: In this small study we found no difference in skin microcirculation and biochemical markers of ED. Of note, the inflammatory marker IL-6 was raised in diabetic patients and whether this influences the endothelial dysfunction observed in this patient group remains to be corroborated in larger studies.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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