Endocrine Abstracts

The aim of the study is the search of predictors of the development of androgen deficiency in men with 1 diabetes mellitus type 1. The study included 211 men with type 1 diabetes mellitus aged 18–55 years. The median age of men was 39.00 (30.00; 45,00) years, the median duration of diabetes mellitus type 1 was 12,00 (7,00; 22,00) years. As a result of the research, it was found that an increase in the patient’s age significantly increased the risk of developing androgen deficiency (b=0.07, Exp (b)=1.08 (1.00÷1.16), P<0.05). The age of smoking experience also had a significant effect on the risk of developing androgen deficiency (b=0.06; Exp (b)=1.07 (1.10–1.13), P<0, 04). The relative risk of developing (RR) androgen deficiency in men with a smoking experience of more than 7 years was 3.76 and was statistically significant (95% CI=1.07÷13.25). With an increase in the level of glycated hemoglobin, the risk of developing androgen deficiency also increased significantly (b=0.08; Exp (b)=1.01 (1.00÷1.02), P<0.04). The exceeding of the glycated hemoglobin level above 7.5% demonstrated a statistically significant RR=6.71 (95% CI=1.19÷37.86). The reduction of LDL decreased the risk of developing androgen deficiency in the men surveyed at the level of a stable trend (b=−0.45; Exp (b) =0.64 (0.35÷1.18), P<0.10). At an LDL level of less than 3.50 mmol / l, the RR of androgen deficiency was 0.29 and was statistically significant (95% CI=0.09–0.97). The rise in VLDL significantly increased the risk of androgen deficiency (b=0.71; Exp (b) =2.04 (1.11÷3.76), P<0.02). At a VLDL level of 0.42 mmol/L, the RR was 2.58 (95% CI=1.38–3.29). As can be seen from the data provided, unsatisfactory compensation of type 1 diabetes mellitus increases the risk of developing androgen deficiency in men.