Endocrine Abstracts

The results of a survey of 209 patients with Diabetes mellitus type 2 (DM 2) and 94 patients with X-syndrome were analyzed. Non-alcoholic fatty liver disease (NAFLD) is verified in 91.9% of cases with DM 2 and 83.0% with X-syndrome. Predictors that significantly influenced the development of NAFLD in X-syndrome have been identified: age (b=0.07; Exp (b)=1.07(1.02÷1.14); P<0.02); body mass index (b=0.37, Exp(b)=1.45 (1.16÷1.81), P<0.001), total cholesterol (b=0.52, Exp (b) =1.68 (1.03 ÷ 21.75), P<0.04), triglycerides (b=1.34; Exp (b)=3.81 (1.32÷11.02);P <0.02) and very low density lipoproteins b=2.60; Exp (b)=13.14 (1.31÷137.18), P<0.03). In patients with X-syndrome over the age of 30, the relative risk of developing RR (NAFLD)=4.00 and was statistically significant (95%CI=1.27÷12.60). In patients with X-syndrome and BMI above 28.08 kg/m², the OR of the development of NAFLD – 9.54 (2.54÷35.75), with total cholesterol above 5.3 mmol/l OR – 4.08 (1.28÷13.05) The level of triglycerides is higher than 1.03 mmol/l OR – 11.37 (1.27÷12.60). If the VLDL level is above 0.47 mmol/l OR – 10.14 (1.27÷12.60). In the presence of diabetes 2, there were no significant critical values of laboratory and clinical predictors of the development of NAFLD. Therefore, patients at the time of manifestation of diabetes 2 already have severe metabolic disorders, such as NAFLD. The data cited indicate that the presence of NAFLD in the background of X-syndrome should be regarded as din from the predictors of development of diabetes 2, and the critical points of clinical and laboratory indicators, perhaps significantly below the generally accepted.