Endocrine Abstracts

Objective: To assess possible predictors of anxiety disorder development at Diabetes Mellitus type 1.

Materials and methods: There were examined 164 patients (93 males and 71 females) with diabetes mellitus type 1 (DM) at the age from 18 to 60 years old. The level of anxiety was assessed with the use of the Hospital Anxiety and Depression Scale (HADS), blood glucose level was determined in the fasted state and 2 hours after the meal. Also there was monitored average daily glucose in blood during 3 days at fourfold detection of glycemia; there were detected glycated hemoglobin level (HbA_1C), total cholesterol (TC), triglycerides (TG), very low-density lipoprotein cholesterol (VLDL cholesterol), low-density lipoprotein cholesterol (LDL cholesterol), high-density lipoprotein cholesterol (HDL cholesterol), blood homocysteine level.

Results: 1. There were determined anxiety disorders within 30,48% patients with DM type 1.

2. The growth of average glycemia significantly increased the risk of development of anxiety disorders (b=0,16) (Exp (b)=1,18; 95% CI – 1,03÷1,34; P<0,02).

3. The risk of anxiety disorder development is not associated with levels of total cholesterol (b=0.20) (Exp (b)=1.23; 95% CI – 0.93÷1.60; P=0.09), level of total VLDL cholesterol (b=0.55) (Exp (b)=1.73; 95% CI – 0.87÷3.46; P<0.10), level of AC (b=0.20) (Exp (b)=1.22; 95% CI – 0.92÷1.62; P<0.10) and level of homocysteine (b=0.64) (Exp (b)=1.07; 95% CI – 0.99÷1.15; P=0.08).