Glucose, lipids, and insulin in cord blood of neonates and their association with birth weight

Jingya Wang; Yashu Kuang; Malcolm Price; Jinhua Lu; Songying Shen; Huimin Xia; Xiu Qiu; Kar Keung Cheng; Krishnarajah Niratharakumar

doi:10.1530/endoabs.56.P329

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Endocrine Abstracts (2018) 56 P329 | DOI: 10.1530/endoabs.56.P329

ECE2018 Poster Presentations: Diabetes, Obesity and Metabolism Developmental endocrinology (2 abstracts)

Glucose, lipids, and insulin in cord blood of neonates and their association with birth weight

Jingya Wang ^1, , Yashu Kuang ¹ , Malcolm Price ² , Jinhua Lu ¹ , Songying Shen ¹ , Huimin Xia ¹ , Xiu Qiu ¹ , Kar Keung Cheng ² & Krishnarajah Niratharakumar ²

Err

Author affiliations

¹Division of Birth Cohort Study, Guangzhou Women and Children’s Medical Centre, Guangzhou Medical University, Guangzhou, China; ²Institute of Applied Health Research, University of Birmingham, Birmingham, UK.

Background: Low and high birth weight (BW) has been linked to the increased risk of infant mortality, obesity, diabetes, and cardiovascular diseases. Metabolic biomarkers, glucose, lipids and insulin in human umbilical cord blood could potentially reflect the new-born metabolic status. This study aims to assess the concentration of glucose, lipids and insulin in cord blood, and to investigate the association between these metabolic parameters and BW.

Methods: A total number of 1522 mother-baby pairs from the Born in Guangzhou Cohort Study (delivered during January 2015–June 2016) were included into this analysis. Data on cord maternal gestational metabolic characteristics, delivery information, cord blood metabolic parameters (glucose, lipids and insulin concentrations) and BW were prospectively collected. Associations between cord blood metabolic parameter z-scores and BW z-score were assessed using multivariable linear regression, adjusted for maternal age, gestational age, parity, gender, delivery mode, maternal metabolic characteristics (2nd trimester glycaemic status and triglycerides level) and sample storage duration.

Results: Other than insulin (median[IQR]: 7.43[4.34, 12.61]) μU/ml) and triglycerides (TG, median[IQR]: 0.33[0.27, 0.41] mmol/l), the concentrate distribution of glucose, total cholesterol (TC, mean ± S.D.: 1.72±0.42 mmol/l), high-density lipoprotein cholesterol (HDL, mean ± S.D.: 0.91±0.28 mmol/l), low-density lipoprotein cholesterol (LDL, mean ± S.D.: 0.61±0.24 mmol/l) in the cord blood were normal distributed. Z-score of glucose concentration in the cord blood was not associated with BW (P=0.81) z-score. Z-score of cord blood TC (β[95%CI]: 0.05[0.01, 0.09]), HDL (β[95%CI]: 0.08[0.04, 0.12]), and insulin (β[95%CI]: 0.21[0.17, 0.25]) were positively associated with BW z-score, while TG z-score was inversely associated with BW z-score (β[95%CI]: −0.22[−0.27, −0.18]).

Conclusion: Our findings suggest new-borns with higher BW centile might have increased risk of insulin insensitivity and high TG consumption rate. Insulin and TG concentrations in cord blood potentially reflect new-born metabolic status.