Endocrine Abstracts

Aim: In this study, we aimed to perform a comparative evaluation of lipid profile, inflamatory markers, clinical parameters, which are related to cardiovascular diseases, and measurements of carotid intima media thickness (CIMT), which is considered to be an indicator of cardiovascular diseases, in patients with overt and subclinical hypothyroidism, all of which have been studied separately in differen studies.

Methods: Patients older than 18 years old, who admitted to the Endocrinology outpatient clinic, with the diagnosis of hypothyroidism (overt and subclinical) were enrolled into the study. Antropometric and serum lipid, hs-CRP, ESR and CIMT of the patients were studied.

Results: Totally 63 patients were included in the study. 55 (87%) of them were females and 8 (13%) of them were males. Mean ages of patients were 34.4±11.9 years. 51 (81%) of patients were diagnosed as subclinical hypothyroidism, and 12 (19%) of them were diagnosed as overt hypothyroidism. Mean BMI was 27.1±5.6 kg/m². Systolic and diastolic blood pressures were within normal limits.Mean, ESR was 12.6±9.1 mm/h, hs-CRP was 4.3±1.5 mg/l, total cholesterol was 195±43 mg/dl, LDL cholesterol was 115.3±36.1 mg/dl, Lp (a) was 17.8±20.3 mg/dl and CIMT was 0.66±0.17 mm. Patients were divided into two groups as subclinical and overt hypothyroidism which were similar in terms of age, gender. Mean CIMT measurement was higher in the overt hypothyroidism group than the subclinical group (P=0.11). Mean CIMT of both groups were higher than age-sex matched healthy population.

Conclusion: Our study group is at risk for early atherosclerosis and cardiovascular diseases because our patients are overweight and their levels of LDL cholesterol and hs-CRP and CIMT values are higher. This risk is higher in the overt hypothyroid group.