Endocrine Abstracts

Objective: The prevalence of silent myocardial ischemia (SMI) is more frequent in diabetic patients and is associated with a worse prognosis. It has been known that diabetes is a major cardiovascular risk factor; it often leads to severe cardiovascular complications, and coronary artery disease (CAD) is the main cause of death in diabetic patients. The aim was to examine the prevalence and duration of SMI in type 2 diabetes (DT2) patients with ischemic heart disease (IHD).

Materials and methods: 180 patients both sexes with type 2 diabetes aged 56.56±11.07 years were studied. All patients were divided into 4 groups: 1 – 50 (27.8%) patients with stable angina pectoris (SAP), 2 – 50 (27.8%) patients with SAP and DT2, 3 – 50 (27.8%) DT2 patients and 4 – 30 (16.6%) healthy control group. In all patients 24-h ECG Holter monitoring was carried out.

Results: We found significant differences in duration of episodes of painful and silent myocardial ischemia between groups. Patients with SAP and DT2 had a long duration of SMI than patients with SAP without DT2 (P=0.019). There were not significant differences between 1 and 2 groups in the number of patients with painful myocardial ischemia (PMI) (P=0.06). Episodes of PMI were not recorded among patients of group 3.

Conclusions: Silent myocardial ischemia is more often in patients with DT2 and IHD due to autonomic neuropathy.