Endocrine Abstracts

Adropin, hormone playing an important role in carbohydrates and lipids metabolism, improves mainly the glucose homeostasis. It could also play a protective role in pathogenesis and development of cardiovascular diseases. The purpose of the study was to assess the adropin concentration and some parameters of nutritional status (BMI, WHtR, BAI, VAI) as well as biochemical parameters (fasting glucose and insulin, and lipid profile). 25 patients (84% of group was women, n=21) without any carbohydrate metabolism disorders, diagnosed at endocrinology department because of other reasons were included to the study. The exclusion criteria were any glucose metabolism disorders (diabetes mellitus, insulin resistance, glucose intolerance, fasting glucose impairment) or medications influence glucose concentration and metabolism (glucocorticosteroids, hypoglycaemic drugs, etc.). The data were statistically analyzed by STATISTICA. α=0.05. The median serum levels of adropin concentration was 1387.9 pg/ml (1187.4–1655.7 pg/ml). There was observed a negative correlation between WHtR index and adropin concentration (R=−0.41, P=0.0385) and a positive correlation between adropin level and HDL cholesterol (R=0.41, P=0.04). In the next step the examined group was divided into two subgroups concerning the cardiovascular risk defined by WHtR index (above 5 – high risk and below 5 – low risk). At that step there was no significant differences observed between serum concentration of adropin concerning into two groups defined by WHtR index (respectively 1413.1 vs 1512.2, P=0.4598). Concerning glucose metabolism parameters there was no correlation observed between adropin level in relation to fasting glucose and fasting insulin (P>0.05). The following step was to compare adropin concentration to the certain parameters of nutritional status. There was observed no correlation between BMI, BAI, VAI indexes and adropin levels (P>0.05). Adropin via regulation fat accumulation, lipid metabolism and HDL -cholesterol concentration could present a protective role in cardiovascular diseases. To strengthen the results an enlargement of study group is required.