Vertebral fractures in patients with type 2 diabetes mellitus

Volha Vadzianava; Alla Shepelkevich; Nadzeya Karytska; Natallia Vasilyeva

doi:10.1530/endoabs.56.P284

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Endocrine Abstracts (2018) 56 P284 | DOI: 10.1530/endoabs.56.P284

ECE2018 Poster Presentations: Diabetes, Obesity and Metabolism Bone & Osteoporosis (7 abstracts)

Vertebral fractures in patients with type 2 diabetes mellitus

Volha Vadzianava ¹ , Alla Shepelkevich ² , Nadzeya Karytska ² & Natallia Vasilyeva ³

Err

Author affiliations

¹Belarusian Medical Academy of Post-Graduate Education, Minsk, Belarus; ²Belarusian State Medical University, Minsk, Belarus; ³Republican Medical Rehabilitation and Balneotherapy Centre, Minsk, Belarus.

The aim of study: Is to assess the frequency of occurrence of vertebral fractures (VFx) and their relationship with hip geometric parameters in type 2 diabetes mellitus (T2DM) postmenopausal women.

Materials and methods: We examined 94 T2DM women, age: 59.6(55.1–63.2)yrs., duration of DM: 7(4.5–11)yrs., duration of menopause 8.5(4–13)yrs., HbA1c:7.3(6.6–9.8)%). The comparison group consisted of 89 women without DM (age:58.3 (52.8–61.2)yrs., duration of menopause 8(3–11)yrs.). Bone mineral density (BMD) at lumbar spine and femoral neck and VFx were measured with dual X-ray absorptiometry. Geometric parameters were determined using Advanced Hip Analysis program. ISI-impact strength index was calculated using the formula of Karlamangla.

Results: It has been established that the BMD (T-score) of the lumbar spine (T2DM:−1((−1.9)−0.1) vs. comparison gr.: −0.8((−1.8)−0.1), P=0.815, respectively) and of the femoral neck (T2DM:−0.7((−1.3)−0.2) vs. comparison gr.:−0.7((−1.3)−0.1)), P=0.730, respectively) in patients with T2DM is comparable with the comparison group, while the BMD of the proximal femur is higher in women with T2DM (T2DM: 0.3((−0.7)−1.4) vs. comparison gr.:−0.1((−0.9)−0.7) P=0.037, respectively). VFx occur statistically significantly more often in patients with T2DM (T2DM:19.15%, n=18 vs. comparison gr.:7.87%, n=7, X²=4.935, P=0.026). In patients with type 2 diabetes considering the OR and 95% of CI the high risk of VFx of 1, 2, and 3 degrees has been found in comparison with the women without DM (OR=2.77, 95% CI=1.098–7.012). T2D females with VFx had lower ISI (T2D with VFx: 0.22 (0.20–0.27) vs. T2D without VFx 0.25(0.23–0.28), P=0.035, respectively) and larger femoral neck diameter (T1D with VFx: 34.6(33.4–36) vs. T1D without VFx 32.9(31.5–34.8) P=0.020, respectively) compared with T1D females without VFx.

Conclusions: VFx statistically occur significantly more often in women with T2DM regardless of BMD. The obtained results testify to the lower ISI, larger femoral neck diameter in group T2DM with the presence of VFx.