Endocrine Abstracts

Introduction and aims: Mean platelet volume (MPV) is a newly indicator of platelet activation which was associated with atherosclerosis. There are limited studies in the literature about MPV levels in patients with both hypoparathyroidism and hyperparathyroidism. This preliminary study, we aimed to investigate a relationship with MPV and serum PTH and calcium levels in patients with disorder of calcium metabolism.

Materials and methods: Fourty-nine hyperparathyroid patient (56.8±13.0 year), 13 hypoparathyroid patients (48.5±14.2 year) and 18 healthy subjects (45.2±14.2 year) were included in our study. All data associated with calcium metabolism including serum total calcium, phosphor, 25-OH vitamin D, parathyroid hormone levels were compared to study groups. All complete blood count, biochemical and hormonal analysis were performed by automatic analyzer.

Results: Serum total calcium levels were different between study groups (10.3±0.8 mg/dl in hyperparathyroid patient, 8.3±1.1 mg/dl in hypoparathyroid patients, and 9.3±0.4 mg/dl in control group, P=0,0001, respectively). There was no significant difference in MPV value (9.7±0.8 fl in hyperparathyroidism, 9.8±0.9 fl in hypoparathyroidism, 9.5±0.5 fl in control group, P>0.05, respectively]. In addition, there was not any correlation between MPV and all studied parameters of associate of calcium metabolism. Preliminary results was presented in this article, but we continue to the study.

Conclusions: Our findings do not support the existence of a relationship between MPV and calcium metabolism. However, preliminary results was presented in this article, we continue to the study.