Primary hyperparathyroidism-localisation studies

Sabina Elena Oros; Robert Andrei Gongu; Laura Alina Diaconescu; Mirela Ivan; Daniel Grigorie; Emilia Gudovan; Anda Dumitrascu; Dan Hortopan; Andrei Goldstein

doi:10.1530/endoabs.56.P251

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Endocrine Abstracts (2018) 56 P251 | DOI: 10.1530/endoabs.56.P251

ECE2018 Poster Presentations: Calcium and Bone Calcium & Vitamin D metabolism (59 abstracts)

Primary hyperparathyroidism-localisation studies’ sensitivity

Sabina Elena Oros ^1, , Robert Andrei Gongu ¹ , Laura Alina Diaconescu ² , Mirela Ivan ² , Daniel Grigorie ^1, , Emilia Gudovan ² , Anda Dumitrascu ² , Dan Hortopan ² & Andrei Goldstein ²

Err

Author affiliations

¹Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; ²C.I. Parhon National Institute of Endocrinology, Bucharest, Romania.

Primary hyperparathyroidism can be caused by adenoma, adenocarcinoma, parathyroid hyperplasia or ectopic parathyroid glands. The American Association of Endocrine Surgeons Guidelines for Definitive Management of Primary Hyperparathyroidism recommends imaging as a helping tool in locating the causative lesion rather than a must for diagnosis. Experienced surgeons rely on the intraoperative localisation of the lesion. Pre surgery localisation helps for a minimally invasive approach. Technetium sestamibi scintigraphy, cervical-mediastinal CT and cervical region ultrasound are the most frequent used techniques but their sensitivity and specificity differs. In our center surgeons appreciate a pre-surgery localisation. We present the results of a retrospective pre surgery localisation study, conducted in C.I Parhon National Institute of Endocrinology, Bucharest, which enrolled 466 subjects with primary hyperparathyroidism, hospitalized between 01.08.2015 and 31.07.2017. Anterior cervical region ultrasound was performed to all subjects, 33% underwent scintigraphy, and 60% were CT scanned. In our hospital, sensitivity for cervical ultrasound was 59%, 50% for technetium scintigraphy and 76% for CT. In conclusion, we use at least two pre surgery localisation imaging technique. The most frequently used one is ultrasound doubled either by cervical CT or scintigraphy. Choosing the second imaging technique depends of the expertize of the center.