ECE2018 Poster Presentations: Calcium and Bone Calcium & Vitamin D metabolism (59 abstracts)
The coexistence of primary hyperparathyroidism with different auto-antibodies and autoimmune diseases
Jovanka Novakovic-Paro 1, , Tijana Icin 1, , Ivana Bajkin 1, , Bozidar Dejanovic 1 , Kristina Stepanovic 1 , Bojan Vukovic 1, , Damir Benc 1, , Dragana Tomic-Naglic 1, , Radoslav Pejin 1, , Andrijana Milankov 1, & Milica Medic-Stojanoska 1,
1Medical Faculty, Unversity of Novi Sad, Novi Sad, Serbia; 2Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Vojvodina, Novi Sad, Serbia.
Introduction: The coexistence of primary hyperparathyroidism with autoimmune diseases is described very rarely in the literature so far. There are only few cases of immune-mediated hyperparathyroidism, associated with anti-calcium- sensing receptor autoantibodies, frequently in context with other immune diseases. Spontaneous remission of primary hyperparathyroidism in anti-TNF therapy of psoriatic arthritis has also been described in one case. Prevalence of positive antithyroid antibodies is 10–13%, and prevalence of undiluted antinuclear antibodies is up to 20% in general population.
The aim of the study was to examine the prevalence of positive autoantibodies in patients with primary hyperparathyroidism.
Material and methods: The study was conducted on 38 patients with primary hyperparathyroidism. Data were collected from medical records. Laboratory or medical history evidence of autoimmune diseases were collected.
Results: Autoimmune thyroid disease was present in 13 (36.1%) of 36 patients. Antinuclear antibodies and antinuclear antibodies on HEP-2 were positive in 4 (22.2%) of 18 patients. Tissue transglutaminase antibodies were done in 14 patients, and were negative in all cases. Antineutrophil cytoplasmic antibodies were done in 13 patients and were negative in all cases. Anticardiolipin antibodies were negative in all 14 cases. Of all 38 patients, 16 (44,4%) of them have either an autoimmune thyroid diseases or some other proven autoimmune disease.
Conclusion: In patients with primary hyperparathyroidism, there is a higher prevalence of autoimmune thyroid disease and positive antinuclear antibodies to HEP-2 than in the general population. Also, the presence of some autoimmune disease in 44.4% of patients is surprisingly high. We propose to examine the prevalence of anti-calcium-sensing receptor autoantibodies in patients with the simultaneous presence of primary hyperparathyroidism and other autoimmune diseases.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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