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Endocrine Abstracts (2018) 56 P223 | DOI: 10.1530/endoabs.56.P223

1Department of Endocrinology, Asclepeion Hospital, Voula, Athens, Greece; 21st Department of Medicine, Asclepeion Hospital, Voula, Athens, Greece; 36th Department of Orthopedics, Asclepeion Hospital, Voula, Athens, Greece; 4Department of Rheumatology, St. Paul’s Hospital, Thessaloniki, Greece.


Introduction: Vitamin D deficiency is associated with the development of osteomalacia, as it decreases intestinal calcium absorption and bone mineralization. However, severe vitamin D deficiency may also be correlated with secondary hyperparathyroidism which induces osteoporosis. In addition, it induces muscular dysfunction which along with frailty in old age it may induce falls.

Aim: The aim was to present a group of patients with severe vitamin D deficiency who developed a hip fracture.

Methods: A group of ten old frail patients, aged 82–97 years, is presented, who developed a hip fracture. Patients were successfully operated for the hip fracture. Laboratory evaluation revealed marginally low blood calcium, low urinary calcium and very low 25(OH)D3 levels (25(OH)D3 <7 ng/ml, normal range >30 ng/ml).

Results: Cholecalciferol was administered to the patients initially in high dosage, thereafter in lower doses. The patients recovered fully. A period of six months after discharge from the hospital they were reevaluated. They had normal 25(OH)D3 levels and they had recovered, physical condition found to be similar to that previous to the hip fracture.

Conclusions: In the group of patients with hip fracture presented the observed severe vitamin D deficiency contributed to the development of hip fracture, whereas the administered vitamin D acted therapeutically and contributed to the postsurgical rehabilitation of the patients. Thus, it is recommended that in old patients presenting with a hip fracture vitamin D levels should be measured and the respective vitamin D deficiency should be corrected therapeutically with the administration of cholecalciferol. In frail patients who live in closed accommodation, due to inability to get out, the measurement of vitamin D should be performed. Vitamin D administration is recommended for the prevention of falls and fractures in this group of patients.

Volume 56

20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

European Society of Endocrinology 

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