Endocrine Abstracts

Objective: To study relationship osteoprotegerin (OPG) and distal radius bone mineral density (BMD) in postmenopausal women with primary hyperparathyroidism (PHPT) compared postmenopausal women without PHPT.

Materials and methods: We studied 30 postmenopausal women with PHPT, average age 62.5±6.12. The control group were 16 postmenopausal women without PHPT, mean age 59.7±6.28 in physiological menopause. We analyzed anthropometric data and history of fractures. Examination: total calcium, phosphorus, albumin, creatinine, PTG, OPG, vitamin D, BMD measurements in the lumbar spine, femoral neck, total hip, and distal 1/3 radius by DXA (T-score_33%, BMD_33% g/cm²).

Results: The were no differences in the age (U=138.5, P=0.052), height, m (U=216.5, P=0.99), weight, kg (U=202.5, P=0.72), BMI kg/m² (U=196.5, P=0.61), duration of menopause in both group, years (U=146.5, P=0.08). Osteoporosis of distal 1/3 radius was founded in 33% (10 cases), osteopenia in 43% (13 cases) in postmenopausal women with PHPT(T-score_33%=–2.3 (–3.2 –1.5, BMD_33%=0.67 (0.59–0.75) g/cm²), and low distal radius BMD was no founded in the control group (T-score_33%=−0.3 (−0.7 –0), BMD_33%=0.87 (0.82–0.9) g/cm²). Significant differences was detected in the distal radius BMD in postmenopausal women with PHPT compared postmenopausal women without PHPT (U_T-score33%=22.0, P<0.0001, U_BMD33%=20.5, P<0.0001). We detected correlation between OPG level and distal radius BMD: r_sT-score33%=0.7_, P<0.05, r_s33%g/cm²=0.64_, P<0.05.

Conclusion: The results of the study confirmed reduced BMD in cortical bone, particularly at the distal radius, in postmenopausal women with PHPT compared control group. The results may indicate association between OPG level and low distal radius BMD.