Endocrine Abstracts

Objective: To study relationship between osteoprotegerin (OPG) and bone metabolism markers in postmenopausal women with primary hyperparathyroidism (PHPT) compared postmenopausal women without PHPT.

Materials and methods: We studied 30 postmenopausal women with PHPT, average age 62.5±6.12. The control group were 16 postmenopausal women without PHPT, mean age 59.7±6.28 in physiological menopause. We analyzed anthropometric data and history of fractures. Examination: total calcium, Ca⁺⁺, phosphorus, albumin, creatinine, alkaline phosphatase, PTG, OPG, crosslaps, osteocalcin.

Results: The were no differences in the age (U=138.5, P=0.052), height, m (U=216.5, P=0.99), weight, kg (U=202.5, P=0.72), BMI kg/m² (U=196.5, P=0.61), duration of menopause, years (U=146.5, P=0.08). Calcium total was 2.75 (2.69- 2.82) mmol/l in postmenopausal women with PHPT vs 2.44 (2.31-2.50) mmol/l in the control group, U=4, P=0.001; Ca⁺⁺1.27 (1.26-1.36) mmol/l vs 1.04 (0.98-1.14) mmol/l in the control group, U=4.24, P<0.0001; phosphorus 0.94 (0.80-1.06) mmol/l vs 1.36 (1.32-1.40) mmol/l in the control group, U=0.001, P=0.029; alkaline phosphatase 122.0 (89.0-146.0) mmol/l vs 84.0 (72.0-84.0) mmol/l in the control group, U=4.0, P=0.126; PTG 111,1 (88.5-144.3) pg/ml vs 54.7 (35.4-55.3) pg/ml, U=0.001, P<0.0001; osteocalcin 32.33 (21.95-40.33) ng/ml vs 19.9 (16.0-27.8) ng/ml, U=23, P=0.07; crosslaps 0.60 (0.37-0.79) vs 0.46 (0.33-0.54), U=16, P=0.2. Significant differences were detected in calcium total, Ca⁺⁺, phosphorus, PTG in postmenopausal women with PHPT compared control group, there were no differences in alkaline phosphatase, osteocalcin, crosslaps. We detected negative correlation between OPG level and calcium total r_s=−0.6_, P <0.05, r_s=−0.7_, P<0.05, PTG r_s=−0.6_, P<0.05.

Conclusion: The results of the study confirmed high bone metabolism in postmenopausal women with PHPT compared control group. The results may indicate association between PTG, calcium level and OPG.