ECE2018 Poster Presentations: Calcium and Bone Bone ' Osteoporosis (38 abstracts)
The main bone mass predictors in healthy young and middle-aged men: lean mass and estradiol
Stefana Catalina Bilha 1 , Maria-Christina Ungureanu 1 , Petru Cianga 1 , Catalin Buzduga 1 , Alina Gatu 1 , Adrian Aancute 2 , Valentin Zaharia 2 , Daniela Constantinescu 1 , Adrian Covic 1 & Dumitru Branisteanu 1
1‘Gr. T. Popa’ University of Medicine and Pharmacy, Iasi, Romania; 2‘St. Spiridon’ Hospital, Iasi, Romania.
Introduction: Despite the high burden of osteoporotic fractures, bone evaluation in men is not without flaws, being frequently undervalued. We aimed at investigating the role of body composition, adipokines and classic bone determinants (sex hormones) as predictive factors for bone mass parameters in healthy young and middle-aged men.
Materials and methods: Anthropometric, bone mineral density (BMD) (assessed by Dual X-Ray Absorptiometry;DXA) and body composition parameters (assessed by DXA) and also the serum levels of C-terminal telopeptide of type I collagen (CTx), adipocytokines (leptin, resistin), total testosterone (free testosterone was calculated using mass action equations), total estradiol and sex hormone-binding globulin (SHBG) were determined from 30 healthy male volunteers aged 20-65 years old. Correlation analysis and also multivariable and hierarchical regression analyses were performed.
Results: BMD at various sites significantly correlated with body mass index (BMI), lean mass (LM), trunk fat mass, leptin, resistin, total estradiol and SHBG in the initial correlation analysis. When multiple regression analysis was performed, only LM and total estradiol remained independent significant predictors of BMD in men (together explaining 49% of whole-body BMD variance, P<0.001), while there were no independent predictors found for CTx. In the hirerchical regression analysis, the beta coefficient for BMI became non-significant when LM was added to the model.
Conclusions: LM and estradiol are the main BMD predictors in healthy young and middle-aged men. LM largely mediates the bone effects of the BMI. These parameters may find their place for fine tuning the male bone evaluation algorithms.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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