ECE2018 Poster Presentations: Calcium and Bone Bone ' Osteoporosis (38 abstracts)
Is FGF23 a key factor in primary hyperparathyroidism?
Alina-Andreea Gatu 1 , Cristian Velicescu 1 , Dan Ionut Repede 2 , Stefana Bilha 1 , Alexandru Florescu 1 , Anca Matei 1 & Dumitru Branisteanu 1
1Gr T Popa University of Medicine and Pharmacy, Iasi, Romania; 2Emergency County Hospital Sf Pantelimon, Focsani, Romania.
Published data regarding the role of FGF23 in primary hyperparathyroidism and its prognostic applicability are scarce and discordant.
Aims: To assess FGF23 profile in patients with primary hyperparathyroidism undergoing surgery.
Matherials and methods: Longitudinal study involving 48 patients aged 30–80 years with primary hyperparathyroidism caused by solitary parathyroid adenoma, submitted to parathyroidectomy. We evaluated FGF23, PTH, 25(OH)D3, calcium and phosphorus at admission, immediately after parathyroid adenoma excision in all patients, and at 3, 6 months and one year after surgery in 13 patients. Differences were considered significant for P<0.05.
Results: FGF23 was within the reference ranges (120±80 pg/ml, normal values specific for carboxyterminal FGF23, dosed in this study), with initial mean values of 75.55±22.74 pg/ml. Preoperative FGF23 was negatively correlated with PTH (r=−0.397; P=0.015) and calcium (P=0.04). We observed no change in postoperative FGF23 or at distance from cure (80.57±27.07 pg/ml 1 year postoperative, NS). Mean FGF23 did not show significant differences in patients with osteoporosis, renal lithiasis or fractures, neither preoperatively, nor 1 year after surgery.
Conclusions: FGF23 levels of patients with primary hyperparathyroidism are in the normal range and do not change significantly after surgery seeming therefore to have no practical prognosis application. The negative correlation of FGF23 with preoperative PTH seems to be an epiphenomenon and suggests that FGF23 regulating role may be largely replaced by PTH in primary hyperparathyroidism.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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