ECE2018 Poster Presentations: Calcium and Bone Bone ' Osteoporosis (38 abstracts)
Potential extension of frax algoritm and probability of bonefracture
Aikaterini Andreadi 1 , Barbara Capuani 1 , Donata Sabato 2 , Maria Romano 2 , Angelica Galli 2 , Flavio Pozzi 2 , Marco Cerilli 2 , Alfonso Bellia 1, , David Della Morte 1 & Davide Lauro 1,
1University of Rome Tor Vergata, Department of Systems Medicine, Rome, Italy; 2UOC of Endocrinology, Diabetology and Metabolic Diseases, Foundation Policlinico Tor Vergata, Rome, Italy.
Osteoporosis is a pandemic chronic non communicable disease, with worldwide expansion. This condition and the resulting bone fracture are a maor cause of disability and mortality for millions of people worlwide. Frax is an algoritm that relies on a questionnaire for the prediction of bonefracture. This algoritm it is called Frax and it’s estimates the probability in % to have a fracture in the following 10 years. The aim of the study was to evaluate whether patients lifestyle and dietary habits may be considered as additional risk factors for new bone fracrtures and evaluate how its correlates to the degree of osteoporosis, Furthermore we analysed if obesity can be associated with reduced levels of bone mineral density (BMD). IN tha last year we have enrolled 1132 patients at the Unit of Endocrinologia, Diabetes and Metabolic Diseases at the University Hospital of TOr Vergata, Rome, Italy. All subjects underwent to evaluation of anthropotric data (weight, BMI, height), bone densitometry with DEXA Hologic QDR 4500 Delphi series, Food frequency questionnaire to access dietary habits during a week and Frax questionnaire. From 1132 subjects, the media of the age was 63.3 (±9.5 S.D.); from wich 1086 were women (63.3 years ±9.4 S.D.) and 45 men (63.8 years ±11.6 S.D.). The food questionnaire data when divided considering the T-score in three groups, 210 subjects normal (−0.29 S.D. ±0.636/0.818 g/cm2/±0.07), 712 with osteopenia (−1.74±0.42/0.649 g/cm2 ±0.05) and 210 with osteoporosis (−2.86±0.38/0.515 g/cm2 ±0.04), confirming that patients with osteoporosis, consume less foods that contains calcium and vitamin D (p value 0.01). Patients were also divided according the body mass index (BMI). From 1132 people the 0.79% were underweight (9 subjects), 34.8% (395 subjects) have normal weight, 36.7% (416 subjects), overweight (27.2±1.4) and 27.5% (312 subjects) were obese (33.7±3.7). It is important to consider that the prevalence of oveweight and obesity in our population was 64.2%. if then we analyze the patients that were overweight and obese, the majority of the sample (80%) presents osteopenia of osteoporosis; this result is controversy from the supposed protective role of adipose issue on bone mineral density.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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