Endocrine Abstracts

Abstract: Up to 96% of changes detected in adrenal glands are non-functioning adrenal incidentalomas. Adrenal masses are associated with increased risk of metabolic syndrome (MS). Studies demonstrate that new anthropometric parameters can be useful indicators of disturbances in glucose and lipid metabolism in various diseases. The purpose of the study was to determine antropometric parameters and its relationship with MS factors according to the criteria of the International Diabetes Federation among patients with non-functioning adrenal incidentalomas. 120 patients hospitalized in Endocrinology City Hospital in Piekary in 2013-2017 with non-functioning adrenal incidentalomas were included to the study. Exclusion criteria were adenomas producting hormones, vitamin D supplementation, liver or kidneys failure. Biochemical parameters were obtained during routinely performed tests in the hospital and taken from the patient’s medical record. Anthropometric parameters were measured in the morning. The results were used to calculate the anthropometric indicators (BMI, BAI, VAI, WHR, WHtR). The data were statistically analyzed by STATISTICA 12. α=0.05. The average BMI was 29.5±5.3 kg/m², WHR(women) 0.9±0.2, WHR(men) 1.0±0.1, WHtR 0.6±0.1, BAI (women) 35.1±6.2, BAI(men) 26.1±3.0%, VAI 2.1±0.3. The average systolic pressure was 142±18 mmHg, diastolic pressure 83.2±9.5 mmHg. The mean concentration of 25(OH)D₃ was 18.6±7.7 ng/dl, total cholesterol (TC) 205.7±44.9 mg/dl, HDL cholesterol(women) 66.2±20.6 mg/dl, HDL cholesterol(men) 49.8±16.7 mg/dl, LDL cholesterol 116.3±40.3 mg/dl, triglycerides (TG) 135.9±75 mg/dl, fasting glucose 112.3±33.5 mg/dl, HBA1C% 6.3±0.9. Possitive correlation (p≤0.05) was observed between VAI and TC (r=0.06), VAI and LDL cholesterol (r=0.34), VAI and TG (r=0.83), WHR and TG (r=0.08), WHtR and TG (r=0.04). Systolic pressure was statistically higher (p≤0.05) in patients with higher BMI (r=0.11), BAI (r=0.06), WHR (r=0.09;), WHtR (r=0.14). Fasting glucose correlated possitively (P≤0.05) with BAI (r=0.05), BMI (r=0.11), VAI (r=0.03), WHR (r=0.13), WHtR (r=0.16), HBA1C% (p≤0.05). Patients with higher 25(OH)D₃ concentration had statistically lower HBA1C%, TC and LDL cholesterol (p≤0.05). There were negative correlations (p≤0.05) between HDL cholesterol and VAI, WHR, WHtR. Low 25(OH)D₃ concentration may indicate lipid disorders in patients with non-functioning adrenal incidentalomas. BMI, BAI, VAI, WHR and WHtR are good inditators of metabolic syndrome in studied group of patients with non-functioning adrenal adenomas.