Female fertility in congenital adrenal hyperplasia

Imen Gargouri; Fatma Mnif; Rihab Ajili; Faten Hadjkacem; Salwa Sessi; Mahdi Kammoun; Mouna Mnif; Mohamed Abid

doi:10.1530/endoabs.56.P144

P144

Prev Next

Section Contents Cite

Endocrine Abstracts (2018) 56 P144 | DOI: 10.1530/endoabs.56.P144

ECE2018 Poster Presentations: Adrenal and Neuroendocrine Tumours Female Reproduction (1 abstracts)

Female fertility in congenital adrenal hyperplasia

Imen Gargouri ¹ , Fatma Mnif ¹ , Rihab Ajili ¹ , Faten Hadjkacem ¹ , Salwa Sessi ² , Mahdi Kammoun ¹ , Mouna Mnif ¹ & Mohamed Abid ¹

Err

Author affiliations

¹Endocrinology Department, Sfax, Tunisia; ²Regional Hospital f Kerkennah, Sfax, Tunisia.

Introduction: Congenital adrenal hyperplasia (CAH) is a genetic disease with autosomal recessive inheritance. The deficit in 21-hydroxylase (21-OH) is by far the most common enzyme deficiency CAH, since it represents 95% of the cases. Fertility in wome is found to be reduced due to hormonal, mechanical and psychological factors.

Patients and methods: It is about a descriptive and prospective study conducted in 15 patients collected in the endocrinology department of Sfax University hospital center. Fertility was evaluated by realising hormonal assessment of FSH, LH, testosterone, prolactin, estradiol and AMH. Pelvic ultrasound was also practiced in search of polycystic ovaries aspect.

Results: At the end of this report we concluded to a hypogonadotropic hypogonadism in a patient and a drop in the AMH hormone in four patients (33.3%). Pelvic ultrasound revealed micropolycystic ovaries in five patients. Referring to 2003 Rotterdam criteria, polycystic ovary syndrome was retained in six patients (40%). Five spontaneous pregnancies happened in three patients resulting in three abortions and the birth of two newborns with unambiguous female phenotype.

Conclusion: The prognosis of fertility in the CAH remains a priority for women in their fertile years. Genetic counseling in this case, is necessary.