The prevalence of concomitent non-medullary thyroid carcinoma and primary hyperparathyroidism

Laura Teodoriu; Raluca Balaceanu; Maria-Christina Ungureanu; Letitia Leustean; Alexandru Grigorovici; Radu Danila; Gabriela-Delia Ciobanu; Cipriana Stefanescu; Cristina Preda

doi:10.1530/endoabs.56.P1164

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Endocrine Abstracts (2018) 56 P1164 | DOI: 10.1530/endoabs.56.P1164

ECE2018 Poster Presentations: Thyroid Thyroid cancer (88 abstracts)

The prevalence of concomitent non-medullary thyroid carcinoma and primary hyperparathyroidism

Laura Teodoriu ¹ , Raluca Balaceanu ¹ , Maria-Christina Ungureanu ^1, , Letitia Leustean ^1, , Alexandru Grigorovici ^1, , Radu Danila ^1, , Gabriela-Delia Ciobanu ^1, , Cipriana Stefanescu ^1, & Cristina Preda ^1,

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¹Emergency Hospital “St. Spiridon”, Iasi, Romania; ²University of Medicine and Pharmacy “Grigore T. Popa”, Iasi, Romania.

Introduction: Synchronous medullary thyroid cancer and pHPT is common in MEN-2A (Sipple syndrome). In contrast, concomitant nonmedullary thyroid cancer and primary hyperparathyroidism (PHPT) is very rare even if the pathological relationship between parathyroid and thyroid diseases is common.

Aim: Was to determine the prevalence of non-medullary thyroid carcinoma in patient who underwent neck exploration for PHPT.

Patients and method: Retrospective study of 259 patients who suffered surgery interventions for hyperparathyroidism at the University Emergency Hospital “St. Spiridon”, Iasi, Romania. Data regarding parathyroid affections, surgical procedures and histological results were recorded.

Results: A total of 259 (198 women and 61 men) parathyroidectomies were performed between 2010-2016 at our hospital (parathyroidectomy only for 136 cases and concomitant thyroidectomy for 123 patients). Among 192 patients with PHPT, 103 also underwent thyroidectomy. The concomitance of HPTP and non-medullary thyroid carcinoma was found in 33 cases (29 women and 4 men). The occult papillary carcinoma was present in 25 (75%) cases, papillary carcinoma in 7 (21, 2%) cases and follicular carcinoma in 1(3%) case. The final prevalence of PHPT and non- medullary carcinoma was 32%.

Conclusion: Our results are in accordance with the main caracteristics of the association between PHPT and non-medullary thyroid carcinoma: more frequent in women, most cases are classical variant of occult papillary carcinoma, bilateral thyroid involvement and lymph node metastasis are very rare. However the high prevalence rise the question if the association between thyroid non-medullary carcinoma and PHPT may be coincidental or is something more to research?