Endocrine Abstracts

Methods: With the purpose of evaluation of the condition of microlymphocirculation and the efficacy of lymph-stimulating medicines patients are divided into 2 groups: the reference group (p41) - traditional treatment (Thyrozol, Anaprilin). The main group (p16) – traditional treatment + Dalargin (Tyr-D-Ala-Gly-Phe-Leu-Arg, equivalent of leu-enkephalin) 1mg (per 2.0 0.9% NaCl) SC into the lateral part of the eyes No.7. Fluorescent lymphangiography, lymphoscopy, determination of the volume of lymphocirculation were performed before and after the treatment (3, 6, 12 months) for the purpose of comparative evaluation of the efficacy of the treatment.

Results: Already 3 months after the treatment with Dalargin, results in the main group reached the indicators of healthy people: reduction of the volume of lymphocirculation by 32% in the reference group and 72% in the main group; improved microlymphocirculation by 21.7% compared to the reference group; exophthalmometric values 3 months later approached the normal ones, and the effect was maintained during 12 months of observations.

Conclusion: 1) dysfunction of the filtration and circulatory functions of the local and systemic lymphatic systems is observed in case of EO.

2) application of Dalargin in case of EO which is resistent to steroid therapy is effective, safe and pathogenetically substantiated.

3) lymphotropic subcutaneous periorbital application of the medicine increases the efficacy of traditional therapy.

4) the efficacy of the medicine in case of lymphotropic method of injections lasts 4-8 times longer and reduces the aggravation of the symptom by 6%.