Evaluation of anti-thyroglobulin antibodies in pregnant women in Area IV of Asturias

Silvia Gonzalez; Fernando Garcia; Raul Rodriguez; Alicia Martin; Lucia Diaz; Jessica Ares; Edelmiro Menendez

doi:10.1530/endoabs.56.P1067

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Endocrine Abstracts (2018) 56 P1067 | DOI: 10.1530/endoabs.56.P1067

ECE2018 Poster Presentations: Thyroid Thyroid (non-cancer) (105 abstracts)

Evaluation of anti-thyroglobulin antibodies in pregnant women in Area IV of Asturias

Silvia González ¹ , Fernando García ¹ , Raúl Rodríguez ¹ , Alicia Martín ¹ , Lucía Díaz ² , Jessica Ares ¹ & Edelmiro Menéndez ¹

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¹Hospital Universitario Central de Asturias, Oviedo, Spain; ²Hospital Uniersitario de Cabueñes, Gijón, Spain.

Introduction: Hypothyroidism in pregnancy is a topic widely studied in recent years, especially in those women with positive autoimmunity. However, usually the only determination of antibodies that is made is the thyroid antiperoxidase antibodies (anti-TPO). In this study we wanted to know what incidence of anti-thyroglobulin antibodies (anti-Tg) our pregnant women present and what repercussion they can have on thyroid function.

Materials and methods: Anti-TPO and anti-Tg antibodies were analyzed in plasma of 147 consecutive women in her first trimester of pregnancy seen in the sanitary area of Oviedo in Asturias. Thyroid function was also evaluated, using the normal reference values for our area (TSH:0.2–4.5).

Results: Anti-TPO positive antibodies were detected in 14 (9.5%) of the 147 women and anti-Tg antibodies in 12 (8.2%) of them. In 87.07% of the patients none of the antibodies were detected, 4.76% had positive anti-TPO antibodies and negative anti-TG, and 3.40% presented positive anti-TG with negative anti-TPO. The thyroid function of these pregnant women according to their autoimmunity was as follow : In the case of patients with negative anti-TPO and positive anti-TG, 2 of 5 presented normal TSH, but in the range between 2.5 and 4.5, who would require treatment following 2017 ATA recommendations.


TSH	AntiTPO - AntiTg -	AntiTPO + AntiTg -	AntiTPO − AntiTg +	AntiTPO + AntiTg +
0.01–0.2	5	0	0	0
0.2–4.5	115	7	5	3
4.5–10	8	0	0	1
>10	0	0	0	3

Conclusion: In our area, 12.92% of pregnant women have positive thyroid autoimmunity. Just 3.40% women presented only anti-Tg positive antibodies. Our patients with negative anti-TPO and positive anti-Tg antibodies had normal thyroid function, but 40% of them could require levothyroxine treatment. So we recommend the evaluation anti-Tg antibodies in those pregnant women who show negative anti-TPO antibodies.