ECE2018 Guided Posters Diabetes Epidemiology (11 abstracts)
Prevalence and predictors of gestational diabetes mellitus: a nationwide multicenter prospective study
Hasan Aydın 1 , Özlem Çelik 2 , Dilek Yazıcı 3 , Çiğdem Altunok 4 , Özlem Tarçın 5 , Oğuzhan Deyneli 3 , Seda Sancak 6 , Sinem Kıyıcı 7 , Kadriye Aydın 8 & Bülent Okan Yıldız 9
1Department of Endocrinology and Metabolism, Yeditepe University Medical Faculty, Istanbul, Turkey; 2Department of Endocrinology and Metabolism, Acıbadem University Medical Faculty, Istanbul, Turkey; 3Department of Endocrinology and Metabolism, Koç University Medical Faculty, Istanbul, Turkey; 4Department of Biostatistics, Yeditepe University Medical Faculty, Istanbul, Turkey; 5Department of Endocrinology and Metabolism, Marmara University Medical Faculty, Istanbul, Turkey; 6Department of Endocrinology and Metabolism, SBU, Fatih Sultan Mehmet Education and Research Hospital, Istanbul, Turkey; 7Department of Endocrinology and Metabolism, SBU, Bursa Yüksek İhtisas Education and Research Hospital, Bursa, Turkey; 8Department of Endocrinology and Metabolism, SBU, Lütfi Kırdar Education and Training Hospital, Istanbul, Turkey; 9Division of Endocrinology and Metabolism, Department of Internal Medicine, Hacettepe University School of Medicine, Ankara, Turkey.
Aim: Gestational diabetes mellitus (GDM) is an important public health issue associated with significant short- and long-term morbidity both for mother and offspring. Prevalence rates of GDM show considerable variation among different countries and regions of the world. The primary aim of this study was to determine the nationwide prevalence and predictors of GDM in Turkey.
Materials and methods: We conducted a prospective nationwide screening among pregnant women. Between August 2016 and November 2017, a total of 2643 pregnant women from 51 centers in 12 different regions were enrolled. Two step screening method was used. All participants were screened with a 50-g glucose challenge test between 24 and 28 weeks of gestation. Those with values exceeding 140 mg/dl at 1 h underwent a 100-g oral glucose tolerance test on a different day. Carpenter Coustan criteria were used for the diagnosis of GDM. Clinical and biochemical data were obtained by electronic database software.
Results: The national prevalence of GDM was found to be 16.2% without a significant difference between urban and rural regions. Mean age and body mass index (BMI) of the study population were 29±5 years and 25.1±4.8 kg/m2 respectively. Women with GDM were older (mean age 32±5y vs. 28±5y, P<0.001) and heavier (mean BMI 27.2±5.1 kg/m2 vs. 24.7±4.7 kg/m2, P<0.001) than their healthy counterparts. Prevalence of GDM tended to increase with age (6.9% in age <25y, 15.6% in 26–35y, and 32.7% in 36–45y, P<0.001). Maternal age, maternal BMI, history of previous GDM and family history of diabetes mellitus were independent predictors of developing GDM (P<0.05 for all). Low risk women (age <25y, BMI <25 kg/m2, no family history of diabetes) comprised 10.7% of the whole population and the prevalence of GDM in these women was 4.5%.
Conclusion: The results of first nationwide study in Turkey indicate that GDM is very common affecting 1 out of 7 pregnancies in the country. Implementation of international guidelines on screening and management of this public health problem is required.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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