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Endocrine Abstracts (2018) 56 GP77 | DOI: 10.1530/endoabs.56.GP77

ECE2018 Guided Posters Diabetes Complications (11 abstracts)

Patients with community acquired pneumonia are three times more likely to die if they have concomitant diabetes mellitus

Elsa Joy 1 , Navjyot Singh 1 & Jubbin Jacob 2


1Department of Medicine, Christian Medical College and Hospital, Ludhiana, India; 2Endocrine and Diabetes Unit, Christian Medical College and Hospital, Ludhiana, India.


Objective: To compare the clinical features, mortality and morbidity outcomes in patients with diabetes mellitus and patients without diabetes mellitus, who are hospitalized with community acquired pneumonia (CAP).

Methods: This cross sectional study included 175 patients (49 patients with diabetes and 126 without diabetes) admitted with CAP to a tertiary care hospital. The study included both quantitative and qualitative variables, which were compared using Independent T test/Mann-Whitney Test (when the data sets were not normally distributed) and Chi-Square test/Fisher exact test respectively. Univariate regression was used to find the risk factors of mortality due to pneumonia in patients with diabetes and without diabetes. Multivariate analysis was used in the end to isolate the effect of diabetes for mortality in community acquired pneumonia (after excluding proven H1N1 cases) while controlling the effect of other variables.

Results: The mean age of presentation in patients with diabetes was 63.7±10.9 years vs. 57.7±16.6 years among patients without diabetes. (P-value-0.006). Comorbidities were present in 79.59% of patients with diabetes with heart disease as the most common comorbidity found in 53.06% of those with diabetes (P value- 0.001). Other clinical features as well as outcome were not very much different in both the groups. On univariate analysis increasing capillary glucose at admission, a higher CURB 65 score, cigarette smoking, presence of type 1 respiratory failure, metabolic acidosis and requirement of invasive ventilation were associated with increased risk of mortality in patients with diabetes. On multivariate analysis diabetes mellitus was found to be a single independent predictor for mortality after controlling for age, COPD (by controlling respiratory acidosis and type 2 respiratory failure) and H1N1 infection with a P value of 0.045, an adjusted odds ratio of 2.344 with CI 1.02–5.382. Diabetes mellitus was an independent predictor for mortality in community acquired pneumonia (after excluding H1N1) with a P value of 0.008, adjusted odds ratio of 3.439 with a CI of 1.382–8.559.

Conclusion: Diabetes mellitus is an independent predictor of mortality in patients admitted with community acquired pneumonia.

Volume 56

20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

European Society of Endocrinology 

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