Endocrine Abstracts

Introduction: This study examined prevalence and risk factors of peri-odontitis in representative samples of Korean adults, with and without diabetes mellitus (DM). Additionally, we did subgroup analysis in diabetic patients with or without metabolic syndrome.

Methods: This study analyzed data from the 2010 to 2015 the Korea National Health and Nutrition Examination Survey (KNHANES) in South Korea which include periodontitis and the parameter of metabolic syndrome (MS). MS was defined according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III). Among data collected from 22,737 respondents, propensity score matching of sex and age was applied and the data were analyzed.

Results: A total of 4706 subjects after propensity score matching of sex and age, including 2060 with periodontitis and 2646 without periodontitis, were analyzed. Periodontitis was present in 43.7% of the total. When compared to the no periodontitis group, the periodontitis group was older (63±10.4), had more males (58.8%), a lower number of subjects who had higher education (56.3%), low-income families (32.1%), higher fasting plasma glucose (122.3±39.2), and higher waist circumference (86±9). Moreover, systolic blood pressure, body mass index, and plasma triglycerides were higher in the periodontitis group whereas HDL cholesterol was lower (P<0.001). Many of those in the periodontitis group had hypertension (57.6%) and diabetes mellitus (55.5%), and metabolic syndrome (46.3%). It showed the same tendency more like in diabetes group. In multiple regression analysis of the risk factors of periodontitis, the risk increased when MS was present (OR 1.12, 95% CI 1.01–1.24), when diabetes mellitus was present (OR 1.19, 95% CI 1.02–1.38), and when there was history of smoking (OR 1.63, 95% CI 1.46–1.81). In particular, for MS in DM, the risk of periodontitis increased as the number of MS components became higher (P<0.001).

Conclusion: The risk of periodontitis was 1.19-fold higher when DM was present than when it was not. The risk was particularly higher when MS was also present and in those that smoke. Moreover, the risk of periodontitis also increased as number of the MS components became higher. Thus, diabetic patients with periodontitis may benefit when they control metabolic parameters.

Keyword: Diabetes mellitus, metabolic syndrome, periodontitis, korean national health and nutrition examination (KNHANES)