ECE2018 Guided Posters Pituitary / Growth Hormone ' IGF Axis (10 abstracts)
Association of IGF1 receptor autoantibodies with height and body size
Christoph Haudum 1, , Waldemar Minich 3 , Julia Münzker 2 , Andrea Groselj-Strele 4 , Ewald Kolesnik 5 , Ines Mursic 5 , Christian Schwiebert 3 , Tim Welsink 3 , Albrecht Schmidt 5 , Thomas Pieber 1, , Lutz Schomburg 3 & Barbara Obermayer-Pietsch 1,
1CBmed GmbH – Center for Biomarker Research in Medicine, Graz, Austria; 2Division of Endocrinology and Diabetology, Department of Internal Medicine, Graz, Austria; 3Institut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany; 4Center for Medical Research, Core Facility Computational Bioanalytics, Medical University of Graz, Graz, Austria; 5Division of Cardiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Objective: Insulin-like growth factor 1 (IGF1) has a crucial role in growth and metabolism. A specifically designed autoantibody (aAb) assay against the IGF1 receptor (IGF1R-aAb) is able to detect IGF1R-aAb in serum. As the IGF1R has shown involvement in many functional pathologies (e.g. in the Laron syndrome), we aimed to investigate the role of IGF1R-aAb in a large population-based cohort of middle-aged volunteers and their potential effects on anthropometric, osteological and metabolic characteristics.
Methods: Clinical and biochemical parameters of 966 volunteers (531 female and 435 male) of the BioPersMed cohort (Biomarkers in Personalized Medicine, Medical University Graz) were analysed to identify putative differences between IGF1R-aAb positive (binding index >3 – times above background) and control subjects. Laboratory data in combination with DXA-derived measurements of bone density, dimensions and body composition allowed a detailed insight into the relation of IGF1R-aAb with biomarkers (body height and composition, hormones and metabolic factors). Unpaired 2 tailed T-test was used to test for statistical significance.
Results: Mean age of the cohort was 57.7 years±8.1 years for women and 58.4 years±9.0 years for men. IGF1R-aAbs were identified in 6.0% of all volunteers (7.6% female and 5.2% male). IGF1R-aAb positive volunteers showed significantly different bone density (P=0.001), body composition (P=0.012) and a significant increase in body height [+4.1 cm in men (P=0.002) and +1.6 cm in women (P=0.1)], with a more pronounced effect in men. There was no difference in age or BMI between the groups.
Summary and conclusions: IGF1R-aAbs are relatively prevalent in healthy adult humans and may affect body height by modulating bone growth. However, their origin, regulation, and relation to hormonal and metabolic pathways have not yet been fully clarified. Therefore, research and monitoring of IGF1R-aAb prevalence before puberty and during lifetime of women and men is a compelling approach but the mechanisms around IGF1R- aAbs and their potential effects remains to be elucidated.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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