ECE2018 Guided Posters Pituitary / Growth Hormone ' IGF Axis (10 abstracts)
Growth disorders in paediatric survivors of hematopoietic stem cell transplantation after chemotherapy-only conditioning- the experience of a single center
Luminita-Nicoleta Cima 1 , Ioana Maria Lambrescu 1, , Lavinia Nedelea 1 , Elisabeta Sava 1 , Bianca Leca 2 , Elena-Alexandra Vadana 2 , Anca Colita 1, , Carmen Gabriela Barbu 1, & Simona Fica 1,
1Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; 2Elias University Hospital, Bucharest, Romania; 3Fundeni Hospital, Bucharest, Romania.
Objective: The reported incidence of growth disorders in hematopoietic stem cell transplantation (HSCT) recipients ranges from 20 to 80% and it was usually described in patients that were given total body irradiation (TBI) in the conditioning regimen. Because the effect of chemotherapy-only conditioning is less clear, we investigated the frequency of growth failure in our series of children treated with HSCT for different disorders without TBI as part of the conditioning protocol.
Material and method: We compared height and IGF-I z-scores in 22 HSCT survivors and 16 healthy subjects matched for age and sex. Short stature was defined as height z-score <−2 S.D.
Results: We identified 4 patients with short stature. HSCT recipients had a higher frequency of short stature (18.83% vs 0%, P=0.027) compared to the control group. Patients transplanted for beta-thalassemia major were more likely to have short stature compared to patients with non-malignant hematologic diseases and malignant hematologic/non-hematologic disorders (100% vs 16.66% and 7.69%, respectively, P=0.04). The longer time elapsed from HSCT (P=0.012) and allogeneic compared to autologous grafting (P=0.019) were associated with a higher prevalence of growth failure in our study. HSCT survivors had lower mean height z-score (P=0.029) and lower body mass index z-score (P=0.027) compared to controls. Multivariate analysis revealed that allogeneic HSCT recipients had lower mean height z-score (P=0.002) and lower mean IGF-I z-score (P=0.006) compared to auto-HSCT recipients and controls.
Conclusion: Almost 20% of the patients in our cohort presented short stature despite the fact that they received chemotherapy-only conditioning, emphasizing the need for long-term surveillance of growth even in this group of patients that were not exposed to TBI.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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