ECE2018 Guided Posters Female Reproduction (11 abstracts)
Hypothalamo-pituitary-adrenal axis sensitivity in women with polycystic ovary syndrome
Djuro Macut 1 , Ivana Bozic-Antic 1 , Dusan Ilic 1 , Tamara Bogavac 1 , Jelica Bjekic-Macut 2 , Danijela Vojnovic-Milutinovic 3 , Olivera Stanojlovic 4 , Bojana Popovic 1 , Tatjana Isailovic 1 , Valentina Elezovic-Kovacevic 1 & Sanja Ognjanovic 1
1Clinic of Endocrinology, Diabetes and Metabolic Diseases, Clinial Center of Serbia, Belgrade, Serbia; 2CHC Bezanijska kosa, Belgrade, Serbia; 3IBISS, University of Belgrade, Belgrade, Serbia; 4Institute of Physiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Introduction: Hypothalamo-pituitary-adrenal (HPA) axis dysregulation could be a link between polycystic ovary syndrome (PCOS) and cardiometabolic and psychological complications associated with disease.
Methods: We analyzed 50 women with PCOS according to ESHRE/ASRM criteria [age 28.66±5.61, body mass index (BMI) 21.94±3.38 kg/m2] and 50 BMI- and age-matched healthy women (control group, CG), (age 28.66±5.63, BMI 22.09±3.70 kg/m2). In follicular phase of menstrual cycle we analyzed body composition (BC) by bioelectrical impedance, serum fasting glucose, insulin, lipids, morning cortisol levels, ACTH, androgens and cortisol after overnight Dex0.5mg and Dex1mg tests. HOMA-IR and FAI were calculated. Repeated measures ANOVA was used for analysis of HPA axis fuctionality after Dex tests.
Results: PCOS and CG didn’t differ in BC parameters, HOMA-IR and lipids. Morning cortisol was significantly higher in PCOS (476.12±168.68 nmol/l vs 401.1±143.5 nmol/l, P=0.019), while ACTH didn’t show any difference (29.0±21.9 ng/ml vs 23.8±14.0, P=0.236). After Dex0.5mg there was no significant difference in cortisol suppression (86.8±16.2% vs 86.5±16.9%, P=0.931) in contrast to Dex1mg where PCOS showed significantly better cortisol suppression (94.9±2.4% vs 92.7±5.8%, P=0.020). During dexametasone tests, HPA axis showed higher level of functionality in PCOS group in comparison to CG (Dex0.5mg: F1,98=5.97, P=0.016; Dex1mg: F1,98=4.88, P=0.029).
Conclusion: Women with PCOS have the same body composition and insulin resistance, but at the same time higher level of HPA axis functionality and better HPA axis sensitivity in comparison to respective controls. HPA axis hyperactivity in PCOS could be possible link towards cardiometabolic and psychological outcomes of the syndrome.
Volume 56
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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