ECE2018 Guided Posters Diabetes Therapy (12 abstracts)
A healthier fat intake is associated with absence of diabetic retinopathy in patients with type 1 diabetes
Minerva Granado-Casas 1, , Mariona Martín 3 , Jordi Real 1, , Anna Ramírez-Morros 1 , Esmeralda Castelblanco 1, , Núria Alonso 1, , Alicia Traveset 2, , Nuria Alcubierre 2 , Manel Puig-Domingo 1, , Marta Hernández 2, & Dídac Mauricio 1,
1Department of Endocrinology and Nutrition, Health Sciences Research Institute and University Hospital Germans Trias i Pujol, Badalona, Spain; 2Biomedical Research Institute, University of Lleida, Lleida, Spain; 3Department of Endocrinology and Nutrition, University Hospital Germans Trias i Pujol, Badalona, Spain; 4Epidemiology and Public Health, International University of Catalonia, Barcelona, Spain; 5Unit Support of Research, Institut d’Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Barcelona, Spain; 6Centre for Biomedical Research on Diabetes and Associated Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain; 7Department of Ophthalmology, University Hospital Arnau de Vilanova, Lleida, Spain; 8Department of Endocrinology and Nutrition, University Hospital Arnau de Vilanova, Lleida, Spain.
Background: Medical nutrition therapy is an important part of the management of type 1 diabetes mellitus (T1DM). Proper adherence to a healthy diet may have a favorable impact on diabetic complications. Our aim was to assess differences in food and nutrient intake of type 1 diabetic patients with and without diabetic retinopathy (DR).
Subjects and methods: This was a two-center, cross-sectional study in patients diagnosed with T1DM with and without DR. Subjects were recruited through the DR screening program of the Departments of Ophthalmology. A validated food frequency questionnaire was administered. Clinical variables were collected. The analysis of data included comparison between groups and multivariable models.
Results: A sample of 103 T1DM with DR and 140 T1DM without DR were recruited. Subjects with DR showed a lower intake of total fat (P=0.036) than their non-DR counterparts. DR was associated with increasing age (P=0.004), hypertension (P<0.001) and diabetes duration (P<0.001), and there was a negative association with high educational level (P=0.018). The multivariable adjusted analysis showed that the intake of complex carbohydrates was positively related to the presence of DR (P=0.018). In contrast, the intakes of total fat (P=0.004), monounsaturated fatty acids (MUFA) (P=0.005), oleic acid (P=0.005), α-linolenic acid (P=0.041) and vitamin E (P=0.004) were associated with the absence of DR.
Conclusions: The intake of total MUFA, oleic acid, α-linolenic acid and vitamin E is associated with a lower frequency of DR in patients with T1DM. These results suggest a potential protective effect of these lipid components for DR.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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