Endocrine Abstracts

Introduction: Diabetes is a risk factor for pancreatic cancer and recent studies confirm this relationship. We report the case of a patient in whom an inaugural diabetes mellitus revealed a malignant vaterian ampuloma.

Observation: A 56-year-old woman with a family history of type 2 diabetes consults for suspicion of type 2 diabetes, polydipsic syndrome, and all-day hyperglycaemia greater than 2 g/dl. During the interrogation, there is a loss of appetite, a significant weight loss without quantification, a cutaneous-mucous sub-jaundice, pruritus and clinical cholestasis syndrome. Presence of a biological cholestasis syndrome with vaterian ampulloma at bili-MRI, an adenocarcinoma was confirmed in the pathological study. Insulin therapy has been initiated for the treatment of diabetes mellitus and surgical treatment such as duodeno-pancreatectomy due to the invasive nature of the tumor, currently the patient is post-surgery stable but very unbalanced in terms of glycemic control.

Conclusion: The link between diabetes and pancreatic cancer is well known, but the mechanisms of this association remain to be clarified. Between type 2 diabetes associated with pancreatic neoplasia or paraneoplastic diabetes, hence the importance of monitoring newly diagnosed diabetics.