Endocrine Abstracts

Introduction: Hyperuricemia is common in type 2 diabetics particularly in patients with very high cardiovascular risk.

Objective: To evaluate the relationship between hyperuricemia and type 2 diabetes, and to determine its predictive factors in this population.

Patients and methods: A retrospective cross-sectional study including168 patients with type 2 diabetes who were hospitalized in the endocrinology department of Ibn Rochd University Hospital, Casablanca from January 2015 to January 2017. Hyperuricemia was defined by a serum uric acid concentration >70 mg/l (men) and >60 mg/l (women). Variables studied were anthropometric measurements), cardiovascular factors (tabagism, hypertension, dyslipidemia) and degenerative complications (retinopathy, neuropathy, renal insufficiency, ischemic heart disease). Analyziswas performed by the SPSS software.

Results: Average age of our patients was 53.8 years (27–81).Hyperuricemia was found in 28% of patients with a clear predominance of women (78.9%, P<0.30), an average age of 56.5 years, and a mean diabetes duration of 12.3 years. Glycemic imbalance was found in 84.6% of the cases with a glycated hemoglobin average of 8.4% (P<0.30). Predictive factors prevalence for hyperuricemia were smoking objectified in 7.6% of patients (P<0.90), obesity in 62.1% (P<0.10), which was moderate in 22.5% (P<0.20) and morbid in 20.3% (p <0.30). 85% of patients were hypertensive (P<0.05), 80.3% were dyslipidemic (P<0.001) with hypertriglyceridemia in 58.3% of cases (P<0.02), and hypoHDLemia in 38% (P<0.001). The search for degenerative complications related to hyperuricemia showed retinopathy in 52.8% of patients (P<0.10), neuropathy in 28.6% (P<0.9), renal failure (GFR between 15 and 60 ml/min) in 53% (P<0.001), which was moderate in 42.8% (P<0.01) and severe in 11.1% (P<0.02). Ischemic heart disease was found in 45.8% of cases (P<0.01).

Discussion: In our study, hyperuricemia in type 2 diabetic patients is common in female patients, particularly with hypertension, dyslipidemia and renal failure. Other factors such as age, obesity, smoking are not related to hyperuricemia in type 2 diabetics.