Endocrine Abstracts

It’s have been reported, that an evidence a mixture of immune cells frequently found inside, or surrounding primary thyroid microcarcinoma. In this point of view, we support the concept, that the immune system, such autoimmune thyroid disease, may interfere or predict in thyroid carcinoma or microcarcinoma development and progression. Arising in nonneoplastic tissues, local immune response under autoimmune chronic thyroiditis would be associated with Hashimoto parenchyme atypia converts in classical papillary carcinoma or its precursors (gray zone lesions). Most of this tumors are diagnosed incidentally. Based of the our data, we conclude, that Hashimoto thyroiditis have some distinct histo- and immunopathological features involving in thyrocytes and extrafollicular domens differences. Our data (n=155), collecting and clasifical according to TBSRTC, were shown, that in Hashimoto parenchyme comprised most of immature follicular cells (solid nest cells) estimating as thyroid stem/progenitor cells with some atypia, high mitotic and invasive potentialities. Results obtained by Cyclin-depending Kinase activities detection, indicate on the high prevance of Cyclin D1/E and Galectin-3 expression in Hashimoto thyroiditis and support the current concept about the asossiation of ‘carcinoma - type’ immature follicular cells with gene amplification in micro papillary thyroid carcinoma and autoimmune thyroiditis.