ECE2018 ePoster Presentations Thyroid (37 abstracts)
Prognostic factors affecting neck lymphnode recurrence and distant metastasis in papillary thyroid cancer: results of a study in 40 patients
Georgios Papadakis 1 , Eleni Triantafillou 2 , Fotini Kanouta 2 , Aspasia Drosou 2 , Styliani Kalaitzidou 2 , Aggeliki Sapera 2 , Dimitra Tampouratzi 2 , Michalis Kotis 2 , Taxiarchis Kyrimis 2 , Aggeliki Aravantinou 2 , Chrysa Karavasili 2 , Anna Drakopoulou 2 , Eirini Veniou 2 , Victoria Kaltzidou 2 & Athanasia Tertipi 2
1STEPS Stoffwechselzentrum, Biel/Bienne, Switzerland; 2Endocrinology Department, Metaxa Anticancer Hospital, Piraeus, Greece.
Objectives: Overall, papillary and follicular carcinoma is associated with a 30-year cancer-related death rate of 6 and 15%, respectively. Poorer outcomes have been associated with older age, male gender, tumor size, grade and extrathyroidal extension. We investigated the clinical and laboratory characteristics of 40 patients who presented recurrence of thyroid disease.
Patients data: • 40 Patients (21 Females and 19 males) with papillary thyroid cancer and recurrence of the disease.
• Mean age ± S.D. of last follow-up: 54.68±16.24 years.
• Mean age ± S.D. of surgery 47.57±15.57 years.
• Mean years ± S.D. after surgery of lymph nodes meta: 1.55±2.52 years.
• All with papillary thyroid carcinoma, 15 (62.5%) with aggressive type and 25 (37.5%) with no aggressive type.
Results: TG and ANTI-TG measurement in different time points (Mean value±S.D.):
• TG in first postoperative control with stimulation: 20.54±26.65 ng/ml and 20% of patients had positive anti-TG.
• TG measure at diagnosis of lymph nodes metastasis: 52.95±137.40 ng/ml and 17.5% of patients had positive anti-TG.
• TG measured at last follow-up control: under suppression therapy: 3.59±12.20 ng/ml. And Tg under stimulation: 6.57±14.36 ng/ml. 17.5% of patients had positive anti-TG in the last follow-up control.
Total I-131 Dosis: 252.75±169.44 mCi. At the first post-therapy WBS all the patients had uptake only in the neck, whereas at the last WBS (post-therapy or diagnostic) 11 patients (27.5%) had negative uptake. When examining the lymph nodes with U/S, nine patients (22.5%) had reduction of the maximal diameter, 23 patients (57.5%) had no change in the maximal diameter and eight patients (20%) had an increase in the maximal diameter of the suspicious lymph node. Two patients (5%) presented with a distant metastasis. Over the time of follow-up, six patients (15%) increased, and 26 patients (65%) reduced the TG levels. Furthermore, over the time of follow-up three patients (7.5%) increased, and three patients (15%) decreased the anti-TG levels.
Conclusions: The recurrence of the disease can be presented clinically with symptoms like dysphagia, dyspnea, voice changement or with a palpable mass in the neck. The biochemical recurrence concerns the increase in Tg of anti-Tg levels and the anatomical recurrence refers to disease detected in Ultrasound, Whole Body Scan, CT, MRI or PET/CT. With all these tests the recurrence can be detected before it is clinically evident.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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