Endocrine disruption and oxidative stress implications of imipenem therapy in the ovary of

Amal Tahri; Manel Naifar; Salima Daoud; Faten Haj Kacem; Tarek Rebai; Fatma Ayedi; Mohamed Abid; Zouheir Sahnoun

doi:10.1530/endoabs.56.EP144

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Endocrine Abstracts (2018) 56 EP144 | DOI: 10.1530/endoabs.56.EP144

ECE2018 ePoster Presentations Reproductive Endocrinology (19 abstracts)

Endocrine disruption and oxidative stress implications of imipenem therapy in the ovary of ‘wistar’ rats

Amal Tahri ¹ , Manel Naifar ² , Salima Daoud ³ , Faten Haj Kacem ⁴ , Tarek Rebai ³ , Fatma Ayedi ² , Mohamed Abid ⁴ & Zouheir Sahnoun ¹

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¹Research Unit of Pharmacology and Toxicology of Xenobiotics (UR12 ES13) and Laboratory of Pharmacology – Sfax Medicine School, sfax, Tunisia; ²Unit of Research ‘Molecular Bases of Human Diseases’,12ES17 Sfax Medicine College, Sfax 3029, Tunisia, Sfax, Tunisia; ³Research Unit of Pharmacology and Toxicology of Xenobiotics (UR12 ES13) and Laboratory of Histo-embryology – Sfax Medicine School, Sfax, Tunisia; ⁴Endocrinology Department, Sfaox, Tunisia.

Imipenem (IMP) is a carbapenem antibiotic mainly used to treat nosocomial infection diseases. We aimed to evaluate the oxidative stress of therapeutic doses of imipenem (IMP) on the ovary of ‘wistar’ rats. In this respect, female rats were divided into four groups: animals were intraperitoneally treated with physiological serum, 30, 50 and 80 mg/kg of IMP for one week. We found that therapeutic doses of this drug did not significantly affect the levels of ovarian malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT). On the other hand, levels of reduced glutathione (GSH) and glutathione peroxidase (GPx) activities in the IMP-treated groups were decreased following the increasing doses of IMP. In addition, oestradiol and progesterone levels were also significantly reduced by IMP therapy compared with the control group (P<0.05). The light microscopy evaluation revealed normal ovary parenchyma. These results suggested that IMP induced oxidative stress and disrupt hormonal balance in the rats’ovaries.