Evaluation of dynamic thiol-disulphide homeostasis in healthy postmenopausal women

Hakan Gozcu; Cemile Bicer; Mahmut Senyurt; Salim Neselioglu; Ayse Carlioglu

doi:10.1530/endoabs.56.EP138

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Endocrine Abstracts (2018) 56 EP138 | DOI: 10.1530/endoabs.56.EP138

ECE2018 ePoster Presentations Reproductive Endocrinology (19 abstracts)

Evaluation of dynamic thiol-disulphide homeostasis in healthy postmenopausal women

Hakan Gozcu ¹ , Cemile Bicer ² , Mahmut Şenyurt ¹ , Salim Neselioglu ² & Ayse Carlioglu ¹

Err

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¹Erzurum Regional Training and Research Hospital, Erzurum, Turkey; ²Yildirim Beyazit University Faculty of Medicine, Ankara, Turkey.

Introduction: The purpose of this study was to evaluate the relation between menopausal women and the thiol/disulphide balance, used as a marker of oxidative stress, by measuring that exchange using a novel technique.

Methods: Fourty five postmenopausal subject and 39 healthy participant were included in the study.

Results: We found that in postmenopausal group, disulphide (P=0.04), disulphide/native thiol (P=0.004), disulphide/total thiol (P=0.004) were higher than the control group, in postmenopausal group, albumin (P=0.008), native thiol (P=0.007), total thiol (P=0.016) and native thiol/total thiol (P=0.004) were lower than the control group with independent of age. Furthermore, a positive correlation was determined between albumin and native thiol (r=0.425, P=0.000), total thiol levels (r=0.416, P=0.001). We found negative correlations between native and total thiols and inflammatory parameters white blood cell (WBC) (r=−0.371, P=0.001 – r=−0.390, P=0.001), neutrophil lymphocyte ratio (NLR) (r=−0.306, P=0.008 – r=−0.293, P=0.011).

Conclusion: This study showed that postmenopausal phase is associated with oxidative stress. Our study supports the hypothesis that decreased albumin and inflammation might be the major cause of oxidative imbalance.