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Endocrine Abstracts (2018) 56 EP138 | DOI: 10.1530/endoabs.56.EP138

ECE2018 ePoster Presentations Reproductive Endocrinology (19 abstracts)

Evaluation of dynamic thiol-disulphide homeostasis in healthy postmenopausal women

Hakan Gozcu 1 , Cemile Bicer 2 , Mahmut Şenyurt 1 , Salim Neselioglu 2 & Ayse Carlioglu 1


1Erzurum Regional Training and Research Hospital, Erzurum, Turkey; 2Yildirim Beyazit University Faculty of Medicine, Ankara, Turkey.


Introduction: The purpose of this study was to evaluate the relation between menopausal women and the thiol/disulphide balance, used as a marker of oxidative stress, by measuring that exchange using a novel technique.

Methods: Fourty five postmenopausal subject and 39 healthy participant were included in the study.

Results: We found that in postmenopausal group, disulphide (P=0.04), disulphide/native thiol (P=0.004), disulphide/total thiol (P=0.004) were higher than the control group, in postmenopausal group, albumin (P=0.008), native thiol (P=0.007), total thiol (P=0.016) and native thiol/total thiol (P=0.004) were lower than the control group with independent of age. Furthermore, a positive correlation was determined between albumin and native thiol (r=0.425, P=0.000), total thiol levels (r=0.416, P=0.001). We found negative correlations between native and total thiols and inflammatory parameters white blood cell (WBC) (r=−0.371, P=0.001 – r=−0.390, P=0.001), neutrophil lymphocyte ratio (NLR) (r=−0.306, P=0.008 – r=−0.293, P=0.011).

Conclusion: This study showed that postmenopausal phase is associated with oxidative stress. Our study supports the hypothesis that decreased albumin and inflammation might be the major cause of oxidative imbalance.

Volume 56

20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

European Society of Endocrinology 

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