Endocrine Abstracts

Background and Aim: Turner’s syndrome (TS) or 45 XO is a condition in which a female is partly or completely missing an X chromosome. TS affects 0.025–0.05% of females and can involve multiple organs through all stages of life, necessitating a multidisciplinary approach to care. We aim to evaluate our practice compared to the clinical practice guidelines, which recommends the following: annual BMI, blood pressure, HbA1c, lipid profile, liver function, thyroid function, skin and teeth inspection; 3 yearly serum calcium, vitamin D, echocardiogram; 5 yearly audiometric evaluation and DEXA scan. As appropriate, renal ultrasound, ophthalmologic evaluation, ECG, liver ultrasound, fertility counselling, uterine ultrasound and coeliac screen.

Methods: Online Patient Correspondence System was used to identify patients with TS in University College Hospital Galway (UCHG). Charts were ordered, reviewed and data was collected and analysed on an encrypted excel sheet.

Results: 16 patients with TS were identified. Two paediatric patients were excluded. Of the 14 included, three patients were not under endocrine service follow-up and 1 patient had follow up in another hospital. The following are the compliance to management guidelines; 86% echocardiogram, 36% cardiac MRI, 95% blood pressure measurement, 71% lipid profile, 36% DEXA scan, 86% serum calcium, 50% serum vitamin D, 93% liver function test, 79% HbA1c, 100% thyroid function test, 64% coeliac screen, 71% renal ultrasound, 29% audiology testing, 36% fertility discussion, 64% HRT, 14% uterine ultrasound, 14% dermatology review, 0% orthodontic, ophthalmology and psychiatric evaluation.

Conclusion: We are planning to use a standardised proforma and re-audit the patients, to improve the management of Turner Syndrome in University College Hospital Galway.