Endocrine Abstracts

Background: Growth hormone, age, sex, genetics or nutrition status play an important role in insuline-like growth factor 1 (IGF-1) liver production and serum levels. Currently, there is no IGF-I reference range for Romanian population.

Aim: To define sex- and age-adjusted reference values for serum IGF-I measured by an automated chemiluminescence immunoassay in adult Romanian population of healthy subjects.

Methods: The study included 174 adult healthy subjects (148 females and 26 males) from the general population of an urban area in Romania. Exclusion criteria are a body mass index below 18 kg/m2 or over 30 kg/m2, fasting blood glucose over 125 mg/dL, chronic kidney disease stage III or more or liver function test over 2 times the upper limit of normal. IGF-I was measured using a Liaison XL IGF-I chemiluminescence assay (DiaSorin, Sallugia, Italy).

Results: For females median (5, 95 percentile) were 200 (172, 323) ng/mL, 197 (110, 297) ng/mL, 165 (104, 265) ng/mL, 154 (83, 234) ng/mL, 153 (83, 218) ng/mL, 156 (81, 228) ng/mL, 153 (61, 224) ng/mL, 139 (29, 241) ng/mL for 20–24, 25–29, 30–34, 35–39, 40–44, 45–49, 50–54 and 55–59 age groups respectively. Due to the small number of subjects median values for age groups in male population could not be calculated. For age-IGF-1 correlation Default (r, p) were −2.1893x+251.85 (−0.42, <0.001) and −0.7321x+184.18 (−0.17, 0.40) for females and males, respectively.

Conclusion: Reference values for age groups in female adult population of Romania were preliminary defined. Age dependency of IGF-1 was confirmed.