ECE2018 Poster Presentations: Thyroid Thyroid (non-cancer) (105 abstracts)
Adaptation and cross-cultural validation of the Spanish version of the Thyroid-Related Quality-of-Life Patient-Reported Outcome (ThyPRO) questionnaire
Ana María González Lleó 1 , Mauro Boronat Cortés 1 , Ulla Feldt-Rasmussen 2 , Carlos Rodríguez Pérez 1 , Æse Krogh Rasmussen 2 , Yaiza López Plasencia 1 , Laszlo Hegedüs 3 , María del Pino Alberiche Ruano 1 , Steen Joop Bonnema 3 , Dunia Marrero Arencibia 1 , Mogens Groenvold 4 , Jakob Bue Bjorner 4 & Torquil Watt 2,
1Department of Endocrinology and Nutrition, Hospital Universitario Insular de Gran Canaria, Las Palmas de Gran Canaria, Spain; 2Department of Medical Endocrinology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark; 3Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark; 4Department of Public Health, University of Copenhagen, Copenhagen, Denmark; 5Department of Internal Medicine Herlev Gentofte, Copenhagen, Denmark.
Introduction: The thyroid-related quality-of-life patient-reported outcome ThyPRO questionnaire is the most widely used tool for measuring health-related quality of life (QoL) in patients with benign thyroid diseases. The aim of this study was to adapt and validate a Spanish version of the ThyPRO.
Methods: The ThyPRO consists of 85 items, grouped in 13 scales and one single QoL item. Scales cover physical and mental symptoms, well-being and function, social and daily function, cosmetic concerns and overall QoL-impact. ThyPRO39 is a short version of the ThyPRO consisting of 39 items grouped in 11 scales and one single item. The Spanish version of the ThyPRO was developed using the forward-backwards translation: 1) forward translation from English to Spanish by two independent native Spanish translators; 2) reconciliation of both versions in a preliminary consensus-translated draft; 3) back-translation by an English native translator not familiar with the original version of the questionnaire; 4) comparison and discussion of the back-translated version and the master English questionnaire; 5) preparation of a new draft translation containing appropriate changes; 6) second back-translation by a different English native translator; 7) discussion of the second back-translation and approval of the final Spanish draft. The translation was pretested on five representative individuals with different thyroid diseases, by cognitive interviewing. The definitive questionnaire (ThyPROes) was completed by 155 patients with benign thyroid diseases attending the Endocrinology Department in a single hospital in Spain. Equivalence between the Spanish version and original (Danish) questionnaire was assessed using tests for differential item functioning (DIF) by means of ordinal logistic regression, controlling for specific diagnosis. The independent variables were language group and scale score, and an interaction term scale score*language group. Non-uniform DIF was considered when the interaction term was significant. DIF magnitude was considered substantial if it could explain more than 2% of the variance in the item score (R2 difference >0.02).
Results: Eight items were flagged with DIF in the ThyProes (one with non-uniform DIF) and two items in the ThyPro39es. Eight scales of ThyPROes and nine scales of ThyPRO39es were free of DIF. The magnitude of DIF was small in most of cases (explained variance in the item score <3% in seven items of ThyProes and in one of ThyPro39es), with probably minor impact in scales scores.
Conclusion: The presented Spanish versions of the ThyPRO and the ThyPRO39 show a good cross-lingual validity and are suitable for use in clinical studies.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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