Endocrine Abstracts

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Bone marrow adipose tissue (BMAT) accounts for up to 70% of bone marrow volume and over 10% of total adipose mass in lean, healthy humans. BMAT further increases in diverse clinical conditions, including ageing, osteoporosis, obesity/diabetes, glucocorticoid treatment, cancer therapy and, strikingly, during caloric restriction. Many of these conditions are also associated with bone loss and increased fracture risk, and therefore it has been suggested that BMAT might directly i...

Previous studies demonstrate unexpectly high human fat cell turnover. About 10% of the total peripheral fat cell pool is renewed every year. In relative terms this turnover is two-fold increased in obesity but reduced in subjects with pernicious adipose morphology (few but large fat cells). High turnover necessitates a renewable source of adipocyte precursors. Two independent studies, using bone marrow transplanted patients as model, demonstrated important contribution of bone...