Endocrine Abstracts

The ‘European Young Endocrine Scientists’ (EYES) founded in 2011, is a committee under the patronage of the European Society of Endocrinology (ESE). The primary goal of this committee is to increase the mutual exchange of ideas and knowledge between early career endocrinologists across Europe, in both basic and clinical research. EYES enables young endocrinologists from all ESE member societies to actively contribute to all aspects of the society’s activities, e...

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SDHA, B, C, and D (SDHx) genes encode the four subunits of succinate dehydrogenase (SDH), a mitochondrial enzyme of the tricarboxylic acid (TCA) cycle that oxidizes succinate into fumarate. They were the first genes encoding a mitochondrial enzyme demonstrated to act as tumor suppressors, an important finding supporting the hypothesis of a direct link between mitochondrial dysfunction and cancer proposed by Otto Warburg in the 1920’s. It is estimated that germline mutatio...

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