Endocrine Abstracts

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Atypical Genital Development (AGD) is defined as congenital conditions within which the development of chromosomal, gonadal and anatomic sex is atypical. Hypospadias represents one of the aspects of the spectrum of AGD and its less severe for in case of isolated hypospadias. Despite the Consensus Meeting in Chicago in 2005 and an overall accepted classification of ADG, numerous questions remain to be solved. The etiology of AGD and hypospadias is still unclear at the crossroad...

The concept of gender identity is uniquely human. Hence we are left with the phenomenon of men and women suffering from Gender Dysphoria (GD) also known as transsexualism to study the origins of gender identity in humans. It has been hypothesized that atypical levels of sex steroids during a perinatal critical period of neuronal sexual differentiation may be involved in the development of GD. In order to test this hypothesis, we investigated brain structure and function in ind...